Calorimetric Evaluation of Directly Compressed Tablets

Overview

The paper studies the effect of the type of the disintegrating substance and the lubricant on thedestruction heat of tablet materials and tablets. Destruction heat was determined by means ofisoperibolic calorimetry. Tablet materials and tablets contained Avicel PH 101 as the dry binder,10% of Primojel, Ac-Di-Sol, or Polyplasdone XL as disintegrating substances, and 5% of magnesiumstrearate or sodium laurylsulfate as the lubricants. The sum of destruction heats of the individualauxiliary substances equalled the found values in tablet materials and tablets. In tablets, in contrastto tablet materials, values of destruction heat higher by 57.9 % were found. In the disintegratingsubstances and lubricants tested, the found values of destruction heats were dependent on the valuesof destruction heats of the individual auxiliary substances. In the disintegrating substances, a lineardependence of the total destruction heat (CDT) on the destruction heat of the disintegratingsubstances (DTR) was found, given by the relationship CDT = 0.797.DTR + 17.666 with thecorrelation coefficient r = 0.986.

Key words:
isoperibolic calorimetry – tablets – lubricants – disintegrating substances