Genomika ve výzkumu mnohočetného myelomu

English version

Authors: S. Ševčíková ¹; P. Němec ^1,2; L. Pour ³; R. Hájek ^1,3,4
Authors‘ workplace: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic ¹; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic ²; Department of Internal Medicine – Hematooncology, University Hospital Brno, Czech Republic ³; Laboratory of Experimental Hematology and Cell Immunotherapy, Department of Clinical Hematology, University Hospital Brno, Czech Republic ⁴
Published in: Klin Onkol 2011; 24(Supplementum 1): 34-38

Overview

Mnohočetný myelom je druhé nejčastější hematoonkologické onemocnění. Je to velmi heterogenní onemocnění charakterizované komplexitou genomu, opakujícími se amplifikacemi a/nebo delecemi, které vedou k rozdílnému klinickému projevu nemoci, ale i přežití u pacientů. Zejména nové metody genomiky hrají klíčovou roli v pochopení příčin patogeneze, progrese nemoci, ale i klasifikace MM.

Klíčová slova:
mnohočetný myelom – real-time PCR – SNP – GEP – patogeneze – prognóza

Tato práce byla podpořena granty MŠMT LC06027, MSM0021622434, granty IGA MZd NS10387, NS10406, NS10408 a GAČR GAP304/10/1395.

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