Pelvic congestion syndrome
Authors:
M. Holý
Authors‘ workplace:
Interní oddělení Nemocnice České Budějovice, a. s.
Published in:
Kardiol Rev Int Med 2014, 16(4): 321-329
Category:
Internal Medicine
Overview
Pelvic congestion is a special form of chronic venous disease in women. This is defined as s syndrome which includes chronic pelvic pain, perineal discomfort, difficulties of micturition, and post‑coital pain in association with ovarian and/ or pelvic vein reflux. It may cause vulvar, perineal, gluteal and lower extremity varices. There is a close relation between symptomatic pelvic varices and renal nutcracker syndrome. Duplex ultrasound of abdominal, pelvic and lower extremity veins and vulvoprineal region is the cardinal method of non‑invasive examination. MRI Venography is a highly sensitive technique for evaluating pelvic congestion. It may be used as a screening method or in cases of ambiguous sonographic findings and doubts. Pharmaceutical treatment options are limited, and therapy is based on venoactive drugs. Endovascular intervention – ovarian/ iliac veins embolisation therapy and ilio‑ caval and renal venous stenting – becomes the first line of treatment for women with severe symptoms, which are resistant to conservative approaches.
Keywords:
chronic pelvic pain – varicose veins – pelvic congestion – renal congestion – anatomy – duplex ultrasound – diagnostic criteria – embolisation therapy – renal venous stenting
Sources
1. Taylor HC jr. Vascular congestion and hyperaemia; their effect on structure and function in the female reproductive system. Am J Obstet Gynecol 1949; 57: 211– 230.
2. Eklof B, Perrin M, Delis KT et al. Updated terminology of chronic venous disorders: the VEIN‑ TERM transatlantic interdisciplinary consensus document. J Vasc Surg 2009; 49: 498– 501. doi: 10.1016/ j.jvs.2008.09.014.
3. Greiner M, Gilling‑ Smith GL. Leg varices originating from the pelvis: diagnosis and treatment. Vascular 2007; 15: 70– 78.
4. Marone EM, Psacharopulo D, Tshomba Y et al. A typical case of nutcracker phenomenon. J Vasc Surg 2011; 53: 219. doi: 10.1016/ j.jvs.2010.01.086.
5. Ramelet AA, Perrin M et al. Phlébology. Issy‑ les‑ Moulineaux: Elsevier Masson 2008: 61– 82, 167– 182, 429– 431.
6. Richardson GD. Managament of pelvic venous congestion and perineal varicosities. In: Gloviczki P et al (eds). Handbook of venous disorders. 3rd ed. London: Hodder Arnold 2009: 617– 626.
7. Phillips D, Deipolyi AR, Hesketh RL et al. Pelvic congestion syndrome: etiology of pain, diagnosis, and clinical management. J Vasc Interv Radiol 2014; 25: 725– 733. doi: 10.1016/ j.jvir.2014.01.030.
8. Belenky A, Bartal G, Atar E et al. Ovarian varices in healthy female kidney donors: incidence, morbidity, and clinical outcome. AJR Am J Roentgeol 2002; 179: 625– 627.
9. Labropoulos N, Tiongson J, Pryor L et al. Nonsaphenous superficial vein reflux. J Vasc Surg 2001; 34: 872– 877.
10. Perrin MR, Labropoulos N, Leon LR jr. Presentation of the patient with recurrent varices after surgery (REVAS). J Vasc Surg 2006; 43: 327– 334.
11. Venbrux AC, Chang AH, Kim HS et al. Pelvic congestion syndrome (pelvic venous incompetence): impact of ovarian and internal iliac vein embolotherapy on menstrual cycle and chronic pelvic pain. J Vasc Interv Radiol 2002; 13: 171– 178.
12. Monedero JL, Zubicoa ES, Grimberg M et al. Subdiaphragmatic venous insufficiency: embolization treatment using mixed technique (coils and foam). Phlebolymphology 2004; 45: 269– 275.
13. Asciutto G, Asciutto KC, Mumme A et al. Pelvic venous incompetence: reflux patterns and treatment results. Eur J Vasc Endovasc Surg 2009; 38: 381– 386. doi: 10.1016/ j.ejvs.2009.05.023.
14. Holý M. Syndrom pánevní kongesce. In: Roztočil K (ed). Angiologie. Praha: Triton 2014: 186– 192.
15. Creton D, Hennequin L, Kohler F et al. Embolisation of symptomatic pelvic veins in women presenting with non‑saphenous varicose veins of pelvic origin – three‑year follow‑up. Eur J Vasc Endovasc Surg 2007; 34: 112– 117.
16. Chung MH, Huh CY. Comparison of treatments for pelvic congestion syndrome. Tohoku J Exp Med 2003; 201: 131– 138.
17. Park SJ, Lim JW, Ko YT et al. Diagnosis of pelvic congestion syndrome using transabdominal and transvaginal sonography. AJR Am J Roentgeol 2004; 182: 683– 688.
18. D’Archambeau O, Maes M, De Schepper AM. The pelvic congestion syndrome: role of the "nutcracker phenomenon" and results of endovascular treatment. JBR‑ BTR 2004; 87: 1– 8.
19. Venbrux AC, Sharma GK, Jackson ET et al. Pelvic varices embolization. In: Ignacio E, Venbrux AC (eds). Women’s health in interventional radiology. Springer Science + Business Media, LLC 2012: 37– 59.
20. Kaufman JA, Waltman AC, Rivitz SM et al. Anatomical observations on the renal veins and inferior vena cava at magnetic resonance angiography. Cardiovasc Intervent Radiol 1995; 18: 153– 157.
21. LePage PA, Villavicencio JL, Gomez ER et al. The valvular anatomy of the iliac venous system and its implications. J Vasc Surg 1991; 14: 678– 683.
22. Jung SC, Lee W, Chung JW et al. Unusual causes of varicose veins in the lower extremities: CT venographic and Doppler US findings. Radiographics 2009; 29: 525– 536. doi: 10.1148/ rg.292085154.
23. Raffetto JD, Qiao X, Beauregard KG et al. Estrogen receptor‑ mediated enhancement of venous relaxation in female rat: Implications in sex‑related differences in varicose veins. J Vasc Surg 2010; 51: 972– 981. doi: 10.1016/ j.jvs.2009.11.074.
24. Raffetto JD, Khalil RA. Mechanism of varicose vein formation: valve dysfunction and wall dilation. Phlebology 2008; 23: 85– 98.
25. Asciutto G, Mumme A, Asciutto KC et al. Oestradiol levels in varicose vein blood of patients with and without pelvic vein incompetence (PVI): diagnostic implications. Eur J Vasc Endovasc Surg 2010; 40: 117– 121. doi: 10.1016/ j.ejvs.2010.01.023.
26. Oswald M, Heintz C, Wohllaib U. How to prove incompetence of the ovarian vein as a source of varicogenesis by testing the hormone content of the varicose veins of the leg. In: Phlebolymphology. Special issue for European Congress of IUP, Bremen 1999.
27. Reginald PW, Adams J, Franks S et al. Medroxyprogesterone acetate in the treatment of pelvic pain due to venous congestion. Br J Obstet Gynaecol 1989; 96: 1148– 1152.
28. Rabe E. UIP Consensus Documents 2011. Bonn: Rabe Medical Publishing 2011: 99– 111, 131– 150.
29. Eliáš P, Žižka J. Dopplerovská ultrasonografie. 1. vyd. Hradec Králové: Nucleus HK 1998: 151– 184.
30. Scultetus AH, Villavicencio JL, Gillespie DL. The nutcracker syndrome: its role in the pelvic venous disorders. J Vasc Surg 2001; 34: 812– 819.
31. Reed NR, Kalra M, Bower TC et al. Left renal vein transposition for nutcracker syndrome. J Vasc Surg 2009; 49: 386– 394. doi: 10.1016/ j.jvs.2008.09.051.
32. He Y, Wu Z, Chen S et al. Nutcracker syndrome – how well do we know it? Urology 2014; 83: 12– 17. doi: 10.1016/ j.urology.2013.08.033.
33. Hemalatha K, Narayani R, Moorthy M et al. Retro‑aortic left renal vein and hypertension. Bombay Hospital Journal 2008; 50: 6– 9.
34. Van Cleef JF. Treatment of vulvar and perineal varicose veins. Phlebolymphology 2011; 18: 38– 43.
35. Eberlová L, Tolar J, Mikuláš J et al. Variabilita hlubokých žil stehna. Cas Lek Cesk 2011; 150: 344– 346.
36. Gloviczki P, Comerota AJ, Dalsing MC et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and American Venous Forum. J Vasc Surg 2011; 53: 2S– 48S. doi: 10.1016/ j.jvs.2011.01.079.
37. Hiromura T, Nishioka T, Nishioka S et al. Reflux in the left ovarian vein: analysis of MDCT findings in asymptomatic women. AJR Am J Roentgeol 2004; 183: 1411– 1415.
38. Rozenblit AM, Ricci ZJ, Tuvia J et al. Incompetent and dilated ovarian veins: a common CT finding in asymptomatic parous women. AJR 2001; 176: 119– 122.
39. Kim HS, Malhorta AD, Rowe PC et al. Embolotherapy for pelvic congestion syndrome: long‑term results. J Vasc Interv Radiol 2006; 17: 289– 297.
40. Asciutto G, Mumme A, Marpe B et al. MR venography in the detection of pelvic venous congestion. Eur Vasc Endovasc Surg 2008; 36: 491– 496. doi: 10.1016/ j.ejvs.2008.06.024.
41. Moore CJ. Pelvic congestion syndrome update. Endovascular Today 2011; October: 24– 30.
42. Takebayashi S, Ueki T, Ikeda N et al. Diagnosis of the nutcracker syndrome with color doppler sonography: correlation with flow patterns on retrograde left renal venography. AJR Am J Roentgeol 1999; 172: 39– 43.
43. Kim SH, Cho SW, Kim HD et al. Nutcracker syndrome: diagnosis with Doppler US. Radiology 1996; 198: 93– 97.
44. Fitoz S, Ekim M, Ozcakar ZB et al. Nutcracker syndrome in children. J Ultrasound Med 2007; 26: 573– 580.
45. Green IC, Cohen SL, Finkenzeller D et al. Interventional therapies for controlling pelvic pain: what is the evidence? Curr Pain Headache Rep 2010; 14: 22– 32. doi: 10.1007/ s11916‑ 009‑ 0089‑ 7.
46. Burak F, Gunduz T, Simsek M et al. Chronic pelvic pain associated with pelvic congestion syndrome and the benefit of Daflon 500 mg: a review. Phlebolymphology 2009; 16: 290– 294. doi: 10.1016/ j.ejvs.2008.06.024.
47. Ghosh A, Shafie‑ Pour H, Ayers K. Laparoscopic sclerotherapy in a case of pelvic congestion syndrome. BJOG 2006; 113: 610– 611.
48. Ahmed K, Sampath R, Khan MR. Current trends in the diagnosis and managament of renal nutcracker syndrome: a review. Eur J Vasc Endovasc Surg 2006; 31: 410– 416.
49. Marone EM, Psacharopulo D, Kahlberg A et al. Surgical treatment of posterior nutcracker syndrome. J Vasc Surg 2011; 54: 844– 847. doi: 10.1016/ j.jvs.2011.01.038.
50. Hartung O, Grisoli D, Boufi M et al. Endovascular stenting in the treatment of pelvic vein congestion caused by nutcracker syndrome: lessons learned from the first five cases. J Vasc Surg 2005; 42: 275– 280.
51. Baril DT, Polanco P, Makaroun MS et al. Endovascular management of recurrent stenosis following left renal vein transposition for the treatment of Nutcracker syndrome. J Vasc Surg 2011; 53: 1100– 1103. doi: 10.1016/ j.jvs.2010.10.112.
52. Chen S, Zhang H, Shi H et al. Endovascular stenting for treatment of Nutcracker syndrome: report of 61 cases with long‑term follow up. J Urol 2011; 186: 570– 575. doi: 10.1016/ j.juro.2011.03.135.
53. Wang X, Zhang Y, Li C et al. Results of endovascular treatment for patients with nutcracker syndrome. J Vasc Surg 2012; 56: 142– 148. doi: 10.1016/ j.jvs.2012.01.007.
54. Monedero LJ, Zubicoa ES, Perrin M. Pelvic congestion syndrome: an update. Phlebolymphology 2013; 20: 145– 149.
55. Edwards RD, Robertson IR, MacLean AB et al. Case report: pelvic pain syndrome – successful treatment of a case by ovarian vein embolization. Clin Radiol 1993; 47: 429– 431.
56. Nicolaides AN, Allegra C, Bergan J et al. Management of chronic venous disorders of the lower limbs: guidelines according to scientific evidence. International Angiology 2008; 27: 1– 59.
57. Monedero JL, Zubicoa ES. Left renal vein compression syndrome (LRV): current evaluation and endovascular treatment. Téchnicas endovasculares – SITE 2013; 16: 56– 58. [online] Available from: http:/ / endovascular.es/ revista_XVI_numero1.php.
Labels
Paediatric cardiology Internal medicine Cardiac surgery CardiologyArticle was published in
Cardiology Review
2014 Issue 4
Most read in this issue
- Pelvic congestion syndrome
- Superficial vein thrombosis – epidemiology, diagnostics, treatment
- Chronic venous disease of the lower limbs – diagnosis and conservative treatment
- Psychogenic erectile dysfunction