#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Endothelial dysfunction, erectile dysfunction and cardiovascular risk


Authors: T. Šrámková
Authors‘ workplace: Urologická klinika a Sexuologický ústav 1. LF UK a VFN v PrazeSexuologické oddělení LF MU a FN Brno
Published in: Kardiol Rev Int Med 2014, 16(4): 262-266
Category: Cardiology Review

Overview

Erectile dysfunction is defined as an inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. Erectile dysfunction incidence is common worldwide. Erectile dysfunction may be the first clinical manifestation of endothelial dysfunction. Erectile dysfunction shares risk factors with cardiovascular disease and is a predictor of a serious cardiovascular event in men who are 30– 60 years of age and in diabetic patients over a period of two to five years.

Keywords:
erectile dysfunction –  endothelial dysfunction –  cardiovascular risk


Sources

1. Breza J. Erektilné poruchy. 1st ed. Martin: Osveta 1994.

2. Weiss P, Zvěřina J. Sexuální chování ČR 2013. Tisková konference duben 2014.

3. Jackson G, Padley S. Erectile dysfunction and silent coronary artery disease: abnormal computed tomography coronary angiogram in the presence of normal exercise ECGs. Int J Clin Pract 2008; 62: 973– 976. doi: 10.1111/ j.1742‑ 1241.2008.01788.x.

4. Gratzke C, Angulo J, Chitaley K et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 2010; 7 : 445– 475. doi: 10.1111/ j.1743‑ 6109.2009.01624.x.

5. Šrámková T. Poruchy sexuality u somatických onemocnění a jejich léčba. 1st ed. Praha: Grada Publishing 2013.

6. Feldman HA, Goldstein I, Hatzichristou DG et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54– 61.

7. Costa C, Virag R. The endotelial‑ erectile dysfunction connection: an essential update. J Sex Med 2009; 6: 2390– 2404. doi: 10.1111/ j.1743‑ 6109.2009.01356.x.

8. Kaiser DR, Billups K, Mason C et al. Impaired brachial artery endothelium –  dependent and independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol 2004; 43: 179– 184.

9. Tamler R, Bar‑ Chama N. Assessment of endothelial function in the patiens with erectile dysfunction: an opportunity for the urologist. Int J Impot Res 2008; 20: 370– 377. doi: 10.1038/ ijir.2008.13.

10. Aversa A, Vitale C, Volterrani M et al. Chronic administration of sildenafil improves markers of endothelial function in men with type 2 diabetes. Diabet Med 2008; 25: 37– 44. doi: 10.1111/ j.1464‑ 5491.2007.02298.x.

11. Foresta C, Ferlin A, De Toni L et al. Circulating endothelial progenitor cells and endothelial function after chronic tadalafil treatment in subjects with erectile dysfunction. Int J Impot Res 2006; 18: 484– 488.

12. Montorsi P, Ravagnani P, Galli S et al. The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005; 96: 19M‑23M.

13. Araujo A, Travison TG, Ganz P et al. Erectile dysfunction and mortality. J Sex Med 2009; 6: 2445– 2454. doi: 10.1111/ j.1743‑ 6109.2009.01354.x.

14. DeBusk R, Drory R, Goldstein I et al. Management of sexual dysfunction in patients with cardiovascular disease: recommendations of The Princeton Consensus Panel. Am J Cardiol 2000; 86: 175– 181.

15. Jackson G, Rosen RC, Kloner RA et al. The Second Princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine. J Sex Med 2006, 3: 28– 36.

16. Nehra A, Jackson G, Miner M et al. The Princeton III Consensus recommendations for the mana­gement of erectile dysfunction and cardiovascular disease. Mayo Clin Proc 2012; 87: 766– 778. doi: 10.1016/ j.mayocp.2012.06.015.

17. Hatzimouratidis K, Eardley I, Giuliano F et al. Guidelines on male sexual dysfunction: Erectile dysfunction and premature ejaculation. EAU 2014. [online] Available from: http:/ / www.uroweb.org/ gls/ pdf/ 14_Male%20Sexual%20Dysfunction_ LR.pdf

18. Rosen RC, Riley A, Wagner G et al. The International Index of Eectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822– 830.

19. Goldstein I, Mulhall JP, Bushmakin AG et al. The erection hardness score and its relationship to successful sexual intercourse. J Sex Med 2008; 5: 2374– 2380. doi: 10.1111/ j.1743‑ 6109.2008.00910.x.

20. Muller J, Mittleman MA, Maclure M et al. Trig­gering myocardial infarction by sexual aktivity. Low absolute risk and prevention by regular physical exertion. Determinants of myocardial infarction onset study investigators. JAMA 1996; 275: 1405– 1409.

21. Meluzín J. Erektilní dysfunkce a srdce. In: Pacík D.(ed). Erektilní dysfunkce pod lupou. Plzeň: Adéla 2005: 9–  16.

22. Conti CR, Pepine CJ, Sweeney M. Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patienst with ischemic heart disease. Am J Cardiol 1999; 83: 29C–34C.

23. Jackson G, Kloner RA, Costigan TM et al. Update on clinical trials of tadalafil demonstrates no increased risk of cardiovascular adverse events. J Sex Med 2004; 1: 161– 167.

24. Cui Y, Zong H, Yan H et al. The effect of statins on erctile dysfunction: a systematic review and meta‑analysis. J Sex Med 2014; 11: 1367– 1375. doi: 10.1111/ jsm.12497.

Labels
Paediatric cardiology Internal medicine Cardiac surgery Cardiology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#