Pharmacotherapy of erectile dysfunction – where we are today and where we are going

Czech version

Authors: J. Bultas ¹; D. Karetová ²
Authors‘ workplace: Farmakologický ústav, 3. LF UK, Praha ¹; II. interní klinika – klinika kardiologie a angiologie 1. LF UK a VFN v Praze ²
Published in: Kardiol Rev Int Med 2014, 16(4): 281-287
Category: Cardiology Review

Overview

This review article summarizes current findings regarding the mechanism of induction of erection and contemporary possibilities of pharmacotherapy for erectile dysfunction. The next part summarizes the characteristics of phosphodiesterase enzymes and the significance of their inhibition in general, with special emphasis on phosphodiesterase type 5 (PDE-5) isoenzyme. After this, the characteristics of the individual representatives of PDE-5 inhibitors – sildenafil, vardenafil, tadalafil and avanafil – are discussed from the point of view of effectiveness, safety and drug interactions. The last part of the article sums up the authors´ knowledge and experiences concerning the influence of several cardiovascular drugs on erectile function and dysfunction.

Keywords:
pharmacotherapy – erectile dysfunction – phosphodiesterase type 5 inhibitors – sildenafil – vardenafil – tadalafil – avanafil

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