Coronary artery disease in patients with type 1 diabetes mellitus

Czech version

Authors: J. Charvát
Authors‘ workplace: Interní klinika 2. LF UK a FN v Motole, Praha
Published in: Kardiol Rev Int Med 2014, 16(2): 131-133
Category: Internal Medicine

Overview

The presence of cardiovascular disease, and especially coronary artery disease, in patients with type 1 diabetes mellitus impairs life expectancy. Hyperglycaemia, which increases oxidative stress, is the key pathophysiological factor. Coronary artery calcifications, the presence of cardiac autonomic neuropathy and diabetic nephropathy are significantly associated with coronary artery disease manifestations. Likewise, the hypoglycaemic episodes significantly increase the cardiovascular risk. Based on the clinical trial outcomes, there is evidence showing that good compensation of type 1 diabetes from the time of its manifestation can significantly reduce the occurrence and progression of macrovascular complications, including coronary artery disease. The correction of hypertension and dyslipidaemia is also beneficial.

Key words:
type 1 diabetes mellitus – hyperglycaemia – coronary artery disease

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