Centraly acting antihypertensives – rilmenidine

Czech version

Authors: M. Souček
Authors‘ workplace: II. interní klinika LF MU a FN u sv. Anny v Brně a ICRC, Brno
Published in: Kardiol Rev Int Med 2014, 16(2): 153-146
Category: Internal Medicine

Overview

Rilmenidine is an antihypertensive from the group of imidazoline receptor agonists. The basis of its mechanism of action is significant reduction of cardiac and renal sympathetic baroreflex response at the level of I₁- imidazoline receptors with subsequent reduction of the sympathetic activity. The effectiveness and tolerability of rilmenidine were proved in randomized comparative studies in elderly patients, patients suffering from hypertension together with diabetes and metabolic syndrome, and in patients with renal failure. The indication for administering rilmenidine is treatment of essential hypertension in adult patients of all age groups. The recommended dose is 1 mg a day (in the morning).

Keywords:
sympathetic nervous system – I₁‑ receptors – hypertension – rilmenidine

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