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Biosimilar Drugs in Oncology
22. 11. 2021 Source: Oncological Treatment8 of the 10 most expensive drugs on the market are used in the treatment of cancer. Rising healthcare costs in recent decades have created a need to find strategies to limit these costs. Biosimilar preparations have the potential to partially replace existing original biological drugs and reduce the cost of cancer treatment. We therefore briefly summarize the basic information on the issue of biosimilars in terms of their benefits, safety, and interchangeability.
Pharmacotherapy of Chronic Heart Failure with Reduced EF LV - Latest ESC Recommendations
The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment of heart failure. We summarize the essential points regarding the pharmacotherapy of chronic heart…22. 11. 2021 Source: Chronic Heart Failure and Lipidology
Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures
The possibility of actively preventing severe bleeding after a major cardiac surgical procedure using cardiopulmonary bypass (CPB) by administering a concentrate of activated procoagulant complex…22. 11. 2021 Source: Hemophilia
Neutralizing Antibodies Against Emicizumab – Detailed Analysis Based on a Case Study
Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient with hemophilia A and an inhibitor, whose treatment was discontinued due to repeated bleeding…22. 11. 2021 Source: Hemophilia
HAE and its Management in Pediatric Patients
Hereditary angioedema (HAE) can be encountered in the emergency room as well as in specialist practices. Patients with this rare disease are often incorrectly diagnosed with other, more common conditions,...19. 11. 2021 Source: Hereditary Angioedema
HAE in the Otolaryngologist's Office: How to Handle a Laryngeal Attack?
Hereditary angioedema (HAE) can be encountered in emergency rooms and specialist offices. Patients with this rare disorder are often misdiagnosed with a more common condition, and they may learn their...19. 11. 2021 Source: Hereditary Angioedema
Cell-Based Implant as a Stable System for Biological Therapy Delivery
A team of scientists from Washington University in St. Louis focused on the possibility of delivering biological inhibitors for the treatment of rheumatoid arthritis using modified induced…19. 11. 2021 Source: Arthritis
Comparable Long-term Safety of Tofacitinib and Biologics in RA Treatment – Data from a US Registry
An analysis of the long-term safety profile of tofacitinib in real clinical practice was published in the journal of the American College of Rheumatology (ACR). Patients with rheumatoid arthritis…18. 11. 2021 Source: Arthritis
Webinar SGLT2i in ESC HF Guidelines vs. Real Practice
Dear Doctor, Boehringer Ingelheim, in collaboration with the 2nd Department of Internal Medicine - Department of Cardiology and Angiology, General University Hospital and 1st Faculty of Medicine,…18. 11. 2021 Source: Heart Failure
Mechanisms of Cardioprotective Effects of SGLT2 Inhibitors
Inhibitors of sodium-glucose cotransporter 2 (SGLT2i, gliflozins) are a relatively new group of medications used in the treatment of type 2 diabetes mellitus (T2DM). Their clinical use is supported…18. 11. 2021 Source: Heart Failure
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