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Does Tofacitinib Improve Comorbid Depressive and/or Anxiety Symptoms in Patients with Rheumatoid Arthritis?

9. 7. 2020 Source: Arthritis

Depression and anxiety disorders are commonly observed in patients with rheumatoid arthritis and can lead to a reduction in quality of life, functional capacity, and, last but not least, to a lower therapeutic response. Therefore, the study presented below examined the prevalence of depressive and generalized anxiety disorders in clinical trials using tofacitinib and the effectiveness of tofacitinib according to baseline values of depression and anxiety.

Vyšetření pacientky magnetickou rezonancí.

Efficacy of Reduced Dose Tumor Necrosis Factor Inhibitors in Axial Spondyloarthritis

The introduction of tumor necrosis factor inhibitors marked a breakthrough in the treatment of axial spondyloarthritis and other autoimmune diseases. One disadvantage of using these drugs can be…
9. 7. 2020 Source: Arthritis
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Effect of Combination of Dorzolamide with Timolol for Wet Age-Related Macular Degeneration

In some eyes with wet age-related macular degeneration (AMD), exudation does not stop despite frequent intravitreal injections of vascular endothelial factor blockers (anti-VEGF). Adjuvant therapy…
3. 7. 2020 Source: Glaucoma
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Minimum and Optimal Factor Levels in Physically Active Hemophiliacs

Authors of a recently published study attempted to determine the value of minimum and optimal levels of coagulation factors in patients with severe hemophilia who engage in physical activities.
2. 7. 2020 Source: Hemophilia
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Tolerability and Efficacy of Eye Drops with and without Preservatives −⁠ A Comparison in Routine Clinical Practice

Insufficient patient compliance due to intolerance of the ocular preparation is a major reason for changing treatment, such as switching to preservative-free drops. The aim of the international…
29. 6. 2020 Source: Treatment of Glaucoma
Detail oka se zánětem spojivek - zarudnutím a bez. Vel. M.

In vivo monitoring of corneal changes in patients treated with and without preservative-containing glaucoma medications

A study published last year by Italian authors monitored structural changes in the corneas of patients treated with preservative-free glaucoma medication for 3 years using confocal microscopy and…
29. 6. 2020 Source: Treatment of Glaucoma
Případová studie pacienta

Possibilities of Using a Topical Immunomodulator for Exacerbation of Atopic Eczema –⁠ Case Study

A 17-year-old high school student consulted a dermatologist due to the exacerbation of atopic eczema symptoms. The worsening occurred after dietary non-compliance and an acute upper respiratory tract…
26. 6. 2020 Source: Topical Treatment of Psoriasis
Pár seniorů na pláži

Pregabalin Relieves Patients with Central Neuropathic Pain

Treatment of central neuropathic pain, whether caused by spinal cord or cerebral damage, is often lengthy and not always successful. Study results show that pregabalin may be a suitable alternative…
25. 6. 2020 Source: Neuropathic Pain
starý muž lavička park šťastný senior muž

Pregabalin in Seniors Confirmed Its Safety and Effectiveness

A pooled analysis of 11 studies investigated the safety and effectiveness of pregabalin in seniors with neuropathic pain. Are the outcomes in these indicators different for older individuals than in…
25. 6. 2020 Source: Neuropathic Pain
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Induction vs. Escalation Treatment: Which Strategy to Choose in the Therapy of Multiple Sclerosis?

Opinions on the optimal therapy for multiple sclerosis (MS) are constantly evolving, and experts are debating the most appropriate first-line treatment strategy. A British cohort study focused on the…
25. 6. 2020 Source: Multiple Sclerosis
drbání ve vlasech

Brodalumab in the Treatment of Psoriasis Symptoms on the Scalp and Nails

A post-hoc analysis of 3 clinical studies (AMAGINE-1/-2/-3) evaluates the effect of treatment with brodalumab or ustekinumab (compared to placebo) in patients with mild to severe psoriasis on the…
24. 6. 2020 Source: Topical Treatment of Psoriasis
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IPFchecker Project Helps Detect Patients with Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis is a serious progressive disease of the lung tissue of unclear etiology. Highly effective antifibrotic therapy is used in treatment, which can significantly prolong the…
24. 6. 2020 Source: Pulmonary Fibrosis
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Options for Anticoagulant Therapy During Catheter Ablation for Atrial Fibrillation: Safety and Efficiency of Bridging with Dabigatran Compared to Interruption of NOACs

Catheter ablation is an established method for treating supraventricular and ventricular arrhythmias. Patients with atrial fibrillation should also use anticoagulant therapy to prevent thromboembolic…
23. 6. 2020 Source: Anticoagulant Treatment
Žena s manikúrou si měří glukometrem inzulin

Prokinetics in the Treatment of Diabetic Gastroparesis

One of the common complications of diabetes mellitus is a motility disorder of the gastrointestinal tract, which can affect any part of the digestive tube, and therefore has various forms. Among…
22. 6. 2020 Source: Gastrointestinal Treatment
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Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia

The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.
22. 6. 2020 Source: Neuropathic Pain
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