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Intracranial Activity of Lorlatinib in Patients with Metastatic ALK-Positive NSCLC
Lorlatinib is a potent third-generation anaplastic lymphoma kinase (ALK) inhibitor with significant antitumor activity against non-small cell lung cancer (NSCLC). According to the results of an international clinical study published in the Annals of Oncology, it shows very good efficacy in treating intracranial metastases in patients who experienced disease progression during therapy with second-generation ALK inhibitors.
Experiences with treating PBC with obeticholic acid in Brno's CKTCH
MUDr. Libuše Husová, Ph.D., shared the current insights from the therapy of patients with primary biliary...
Dabigatran Etexilate in the Treatment of Acute Thromboembolic Disease in Children
Until now, standard anticoagulants such as low-molecular-weight heparin or unfractionated heparin…
When to Stop Dabigatran Anticoagulation Treatment Before Catheter Ablation in Patients with Atrial Fibrillation?
Catheter ablation is now a standard method of treating atrial fibrillation. Its most common…
Dust Mite Allergies: Common Does Not Mean Trivial
Dust mite allergies are almost ubiquitous problems that we perceive as part of the 'broader norm.'…
OCA in Second-Line Treatment of PBC: Analysis Results and Real-World Data
Ursodeoxycholic acid (UDCA) is the cornerstone treatment for PBC according to the guidelines of the...
Bilastine as a reliable helper in the treatment of allergic rhinoconjunctivitis and urticaria even in younger children
Until recently, bilastine was indicated for the treatment of allergic rhinoconjunctivitis and…
Key for Patients with PBC are Timely Diagnosis and Assessment of Therapy Effectiveness
Primary biliary cholangitis (PBC) cannot be cured. It progresses slowly and over several decades leads...
Von Willebrand Disease as a Cause of Abnormal Uterine Bleeding
Abnormal uterine bleeding constitutes a large portion of complaints among women of reproductive…
Negative Symptoms of Schizophrenia and Their Assessment
Schizophrenia is a serious psychiatric disorder with a prevalence of up to 1%. It can manifest with…
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