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Metamizole in the Treatment of Acute Postoperative Pain

25. 5. 2021 Source: Analgesia

In many countries, metamizole is considered a first-choice non-opioid analgesic. The analysis presented below, published in the Cochrane Database of Systematic Reviews, examined the efficacy and safety of metamizole in the treatment of acute postoperative pain.

Quality of Life of Hemophiliacs and Ways to Improve It

Determining the quality of life (QoL) also reflects the morbidity associated with the disease, in this case, hemophilia. In the study presented below, the authors focused on determining QoL in…
21. 5. 2021 Source: Hemophilia with Movement
Analýza dat

Comparison of EHL Products in the Treatment of Hemophilia A –⁠ Pharmacoeconomic Analysis

In the work presented below, whose results were recently published, a model combining pharmacokinetic and pharmacodynamic data was developed. With its help, the authors tried to compare the bleeding…
21. 5. 2021 Source: Hemophilia with Movement
léky_ruce

Comparison of Duloxetine, Gabapentin, and Pregabalin in the Treatment of Diabetic Neuropathic Pain

Painful diabetic neuropathy represents an unpleasant complication of diabetes, in which several groups of drugs are used in therapy. Among their representatives are duloxetine, gabapentin, and…
21. 5. 2021 Source: Neuropathic Pain
Pregabalin

Pregabalin in the Treatment of Postherpetic Neuralgia Resistant to Gabapentin

Pregabalin appears to be an effective aid in patients with postherpetic neuralgia. This is evidenced by numerous clinical studies comparing the effects of pregabalin and gabapentin. It can be…
21. 5. 2021 Source: Neuropathic Pain
Těhotenství_gravidita_těhotná_žena

Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy –⁠ Case Study

The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The…
20. 5. 2021 Source: Management of Thrombosis in Women
PL_glukometr_diabetes

Does Sacubitril/Valsartan Prevent Myocardial Remodeling in Heart Failure Patients with Type 2 Diabetes?

The PROVE-HF study demonstrated reverse myocardial remodeling in patients with chronic heart failure with reduced ejection fraction. About 30–50% of heart failure patients have type 2 diabetes…
20. 5. 2021 Source: Chronic Heart Failure and Lipidology
Tlakoměr_nizký krevní tlak_hypotenze

INFOGRAPHIC: Prevention and Management of Hypotension During Sacubitril/Valsartan Treatment

Despite the undeniable benefits of sacubitril/valsartan in terms of morbidity and mortality in patients with chronic heart failure, its administration can be complicated by side effects. The most…
20. 5. 2021 Source: Chronic Heart Failure and Lipidology
covid_vakcina_injekce

Thrombocytopenia Following mRNA Vaccination Against SARS-CoV-2

In connection with the administration of mRNA-based vaccines against the SARS-CoV-2 coronavirus, cases of secondary immune thrombocytopenia (ITP) have been described. A commentary published by a…
20. 5. 2021 Source: Immune Thrombocytopenia
medical_expert_expertní_analýza_expertní_doporučení

Options for Reducing or Discontinuing TPO-RA Therapy in ITP Patients −⁠ Expert Consensus

There are currently no clear recommendations regarding dose reduction or discontinuation of thrombopoietin receptor agonists (TPO-RA) in patients with immune thrombocytopenia (ITP). A consensus by…
20. 5. 2021 Source: Immune Thrombocytopenia
teenager_dospívající

Safety and Effectiveness of Lurasidone in Adolescents with Schizophrenia

An open-label extension of a placebo-controlled study involving 271 patients aged 13–17 years with schizophrenia showed minimal impact on body weight, lipid levels, prolactin, and blood glucose…
18. 5. 2021 Source: Modern Treatment of Schizophrenia
Schizofrenie_ataka_žena

Adverse effects of antipsychotics in the treatment of schizophrenia negatively affect cognitive functions

Schizophrenia is a severe psychiatric disorder characterized by a wide range of symptoms, with cognitive dysfunctions being one of its domains. Antipsychotics (APs) are used for treatment, but their…
18. 5. 2021 Source: Modern Treatment of Schizophrenia
Arteriální_plicní_hypertenze_PAH

Systemic Manifestations of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by remodeling of the pulmonary vessels, leading to the development of right-sided heart failure. Aside from the…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
Bezpečnost_léky_farmakovigilance

Safety of Riociguat in the Treatment of Thromboembolic Pulmonary Hypertension in Common Practice

In March 2021, the final safety results of riociguat in the treatment of thromboembolic pulmonary arterial hypertension in real-world practice were published from the international EXPERT registry,…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
PL_astma_inhalator_zena_kasel

Alpha-1-Antitrypsin Deficiency and Its Association with Atopy in Asthmatics

Literature mentions the coincidence of asthma and alpha-1-antitrypsin deficiency, which is caused by a mutation in the SERPINA1 gene. The aim of the study presented below was to determine whether the…
14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
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