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Comparison of Duloxetine, Gabapentin, and Pregabalin in the Treatment of Diabetic Neuropathic Pain
21. 5. 2021 Source: Neuropathic PainPainful diabetic neuropathy represents an unpleasant complication of diabetes, in which several groups of drugs are used in therapy. Among their representatives are duloxetine, gabapentin, and pregabalin. The meta-analysis, whose conclusions we summarize below, focused on comparing their effectiveness and tolerability.
Pregabalin in the Treatment of Postherpetic Neuralgia Resistant to Gabapentin
Pregabalin appears to be an effective aid in patients with postherpetic neuralgia. This is evidenced by numerous clinical studies comparing the effects of pregabalin and gabapentin. It can be…21. 5. 2021 Source: Neuropathic Pain
Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy – Case Study
The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The…20. 5. 2021 Source: Management of Thrombosis in Women
Does Sacubitril/Valsartan Prevent Myocardial Remodeling in Heart Failure Patients with Type 2 Diabetes?
The PROVE-HF study demonstrated reverse myocardial remodeling in patients with chronic heart failure with reduced ejection fraction. About 30–50% of heart failure patients have type 2 diabetes…20. 5. 2021 Source: Chronic Heart Failure and Lipidology
INFOGRAPHIC: Prevention and Management of Hypotension During Sacubitril/Valsartan Treatment
Despite the undeniable benefits of sacubitril/valsartan in terms of morbidity and mortality in patients with chronic heart failure, its administration can be complicated by side effects. The most…20. 5. 2021 Source: Chronic Heart Failure and Lipidology
Thrombocytopenia Following mRNA Vaccination Against SARS-CoV-2
In connection with the administration of mRNA-based vaccines against the SARS-CoV-2 coronavirus, cases of secondary immune thrombocytopenia (ITP) have been described. A commentary published by a…20. 5. 2021 Source: Immune Thrombocytopenia
Options for Reducing or Discontinuing TPO-RA Therapy in ITP Patients − Expert Consensus
There are currently no clear recommendations regarding dose reduction or discontinuation of thrombopoietin receptor agonists (TPO-RA) in patients with immune thrombocytopenia (ITP). A consensus by…20. 5. 2021 Source: Immune Thrombocytopenia
Safety and Effectiveness of Lurasidone in Adolescents with Schizophrenia
An open-label extension of a placebo-controlled study involving 271 patients aged 13–17 years with schizophrenia showed minimal impact on body weight, lipid levels, prolactin, and blood glucose…18. 5. 2021 Source: Modern Treatment of Schizophrenia
Adverse effects of antipsychotics in the treatment of schizophrenia negatively affect cognitive functions
Schizophrenia is a severe psychiatric disorder characterized by a wide range of symptoms, with cognitive dysfunctions being one of its domains. Antipsychotics (APs) are used for treatment, but their…18. 5. 2021 Source: Modern Treatment of Schizophrenia
Systemic Manifestations of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by remodeling of the pulmonary vessels, leading to the development of right-sided heart failure. Aside from the…16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
Safety of Riociguat in the Treatment of Thromboembolic Pulmonary Hypertension in Common Practice
In March 2021, the final safety results of riociguat in the treatment of thromboembolic pulmonary arterial hypertension in real-world practice were published from the international EXPERT registry,…16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
Alpha-1-Antitrypsin Deficiency and Its Association with Atopy in Asthmatics
Literature mentions the coincidence of asthma and alpha-1-antitrypsin deficiency, which is caused by a mutation in the SERPINA1 gene. The aim of the study presented below was to determine whether the…14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
Antiviral and Anti-inflammatory Effects of Alpha-1-Antitrypsin in the Treatment of COVID-19
Human alpha-1-antitrypsin (AAT) is a circulating blood glycoprotein that has been used for decades in the treatment of patients with AAT deficiency, lung damage, and emphysema, helping to prevent…14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
To what extent can the actual level of ALP, ALT, or bilirubin differ from the measured value?
A physician who bases clinical decisions on laboratory-determined values of biological parameters or their changes should always consider the possible measurement deviation, which for alkaline…14. 5. 2021 Source: Primary Biliary Cholangitis
Treatment of Motor Symptoms of Parkinson's Disease
Parkinson's disease (PD) is one of the few neurodegenerative disorders for which effective symptomatic treatment is available. Unfortunately, causal or even neuroprotective therapy with proven…12. 5. 2021 Source: Parkinson's Disease
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