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Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy –⁠ Case Study

20. 5. 2021 Source: Management of Thrombosis in Women

The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The patient developed an allergic reaction to low-molecular-weight heparin (LMWH) and was successfully managed with fondaparinux during pregnancy.

PL_glukometr_diabetes

Does Sacubitril/Valsartan Prevent Myocardial Remodeling in Heart Failure Patients with Type 2 Diabetes?

The PROVE-HF study demonstrated reverse myocardial remodeling in patients with chronic heart failure with reduced ejection fraction. About 30–50% of heart failure patients have type 2 diabetes…
20. 5. 2021 Source: Chronic Heart Failure and Lipidology
Tlakoměr_nizký krevní tlak_hypotenze

INFOGRAPHIC: Prevention and Management of Hypotension During Sacubitril/Valsartan Treatment

Despite the undeniable benefits of sacubitril/valsartan in terms of morbidity and mortality in patients with chronic heart failure, its administration can be complicated by side effects. The most…
20. 5. 2021 Source: Chronic Heart Failure and Lipidology
covid_vakcina_injekce

Thrombocytopenia Following mRNA Vaccination Against SARS-CoV-2

In connection with the administration of mRNA-based vaccines against the SARS-CoV-2 coronavirus, cases of secondary immune thrombocytopenia (ITP) have been described. A commentary published by a…
20. 5. 2021 Source: Immune Thrombocytopenia
medical_expert_expertní_analýza_expertní_doporučení

Options for Reducing or Discontinuing TPO-RA Therapy in ITP Patients −⁠ Expert Consensus

There are currently no clear recommendations regarding dose reduction or discontinuation of thrombopoietin receptor agonists (TPO-RA) in patients with immune thrombocytopenia (ITP). A consensus by…
20. 5. 2021 Source: Immune Thrombocytopenia
teenager_dospívající

Safety and Effectiveness of Lurasidone in Adolescents with Schizophrenia

An open-label extension of a placebo-controlled study involving 271 patients aged 13–17 years with schizophrenia showed minimal impact on body weight, lipid levels, prolactin, and blood glucose…
18. 5. 2021 Source: Modern Treatment of Schizophrenia
Schizofrenie_ataka_žena

Adverse effects of antipsychotics in the treatment of schizophrenia negatively affect cognitive functions

Schizophrenia is a severe psychiatric disorder characterized by a wide range of symptoms, with cognitive dysfunctions being one of its domains. Antipsychotics (APs) are used for treatment, but their…
18. 5. 2021 Source: Modern Treatment of Schizophrenia
Arteriální_plicní_hypertenze_PAH

Systemic Manifestations of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by remodeling of the pulmonary vessels, leading to the development of right-sided heart failure. Aside from the…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
Bezpečnost_léky_farmakovigilance

Safety of Riociguat in the Treatment of Thromboembolic Pulmonary Hypertension in Common Practice

In March 2021, the final safety results of riociguat in the treatment of thromboembolic pulmonary arterial hypertension in real-world practice were published from the international EXPERT registry,…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
PL_astma_inhalator_zena_kasel

Alpha-1-Antitrypsin Deficiency and Its Association with Atopy in Asthmatics

Literature mentions the coincidence of asthma and alpha-1-antitrypsin deficiency, which is caused by a mutation in the SERPINA1 gene. The aim of the study presented below was to determine whether the…
14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
pacient_lekarka_covid_rouska_maska

Antiviral and Anti-inflammatory Effects of Alpha-1-Antitrypsin in the Treatment of COVID-19

Human alpha-1-antitrypsin (AAT) is a circulating blood glycoprotein that has been used for decades in the treatment of patients with AAT deficiency, lung damage, and emphysema, helping to prevent…
14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
Laboratoř_měření_jaterní_hodnoty_ALP_test

To what extent can the actual level of ALP, ALT, or bilirubin differ from the measured value?

A physician who bases clinical decisions on laboratory-determined values of biological parameters or their changes should always consider the possible measurement deviation, which for alkaline…
14. 5. 2021 Source: Primary Biliary Cholangitis
Parkinsonova choroba_žena_asistentka_chodítko

Treatment of Motor Symptoms of Parkinson's Disease

Parkinson's disease (PD) is one of the few neurodegenerative disorders for which effective symptomatic treatment is available. Unfortunately, causal or even neuroprotective therapy with proven…
12. 5. 2021 Source: Parkinson's Disease
medicína žena břicho bolest žaludek stomie

Liposomal Pegylated Irinotecan in the Treatment of Pancreatic Tumors

Combined treatment with liposomal pegylated irinotecan, 5-fluorouracil (5-FU), and leucovorin (LV) significantly improves overall survival in patients with metastatic ductal carcinoma of the…
11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas
PL_pankreas_rakovina

New Treatment Option for Metastatic Pancreatic Cancer –⁠ Pegylated Liposomal Irinotecan

The 2019 review article is dedicated to the use of nanoliposomal irinotecan, its toxicity, and its potential use in the treatment sequence of metastatic pancreatic ductal adenocarcinoma.
11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas
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