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Immunotolerance is still the goal of management of hemophilia A with inhibitor in the era of non-factor therapy

18. 3. 2020 Source: Hemophilia

New molecules in hemophilia therapy have raised many questions, including regarding the significance and need for immune tolerance induction (ITI). Interesting conclusions from the FIT (Future of Immunotolerance Treatment) expert panel discussion on the future of ITI, its form, and indication were published in July 2019.

Coronavirus1

Basic Information on the Spread and Course of COVID-19 Infection in China: What We Know So Far?

Currently, we are experiencing a worldwide outbreak of COVID-19 infection caused by the SARS-CoV-2 virus, with the first cases identified in December 2019 in Wuhan, China. As of March 18, 2020,…
17. 3. 2020 Source: Anti-Infectives
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Rapid Diagnosis of Depression in Primary Care Settings

Depression is one of the most commonly occurring psychiatric disorders encountered in general practitioners' offices. The general public also very often uses the term “depression” to mean “bad mood.”…
17. 3. 2020 Source: Depression and Anxiety
medicina_zena_spanek

The Link Between Various Sleep Disorders and the Onset of Depression: What Findings Did the Population Study in Denmark Bring?

A Danish population study published in June 2019 examined the link between different types of sleep disorders and the risk of developing depression. Which disorders confirmed this link after…
17. 3. 2020 Source: Depression and Anxiety

Insufficient dosing of enoxaparin is common in patients post-orthopedic surgery and increases the risk of thromboembolic disease

Orthopedic and traumatological procedures involving the pelvis and lower limbs are associated with a significant increase in the risk of thromboembolic disease. Therefore, prophylaxis with…
17. 3. 2020 Source: Thromboprophylaxis
tromboembolismus_plice

Dabigatran as Effective Prevention of VTE Recurrence Also in Patients with Thrombophilia

With increasing positive experience with direct oral anticoagulants, the question arises of how these drugs work in different groups of patients −⁠ for example, in those who have a congenital or…
17. 3. 2020 Source: Anticoagulant Treatment
sebevrazda_deprese_smutek_frustrace

Trazodone as a Multimodal and Multifunctional Antidepressant

Substances with multiple therapeutic effects, often depending on the dose, can be described as multifunctional. In low doses, trazodone has hypnotic effects, while its effective antidepressant action…
17. 3. 2020 Source: Depression and Anxiety
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Prognostic Significance of Lymphopenia for Stratification of Patients with Follicular Lymphoma

The therapy of follicular lymphoma (FL) is guided by several prognostic indices, such as the Follicular Lymphoma International Prognostic Index (FLIPI). The retrospective analysis of 736 patients…
17. 3. 2020 Source: Non-Hodgkin Lymphomas and CLL
medicína_žena_bolest_břicho_vaječníky_karcinom_ovaria_menstruace

Benefit of Maintenance Therapy with Olaparib in Newly Diagnosed Advanced Ovarian Cancer

The SOLO-1 study evaluated whether the use of the PARP inhibitor olaparib in the maintenance treatment of patients with newly diagnosed advanced ovarian, fallopian tube, or peritoneal cancer with…
17. 3. 2020 Source: Ovarian and Breast Cancer

Metamizole in perioperative treatment in children under 14 years –⁠ results of a questionnaire survey from practice

A recent survey among German-speaking physicians evaluated the use of non-opioid analgesics in perioperative care in children under 14 years. It focused on the use of metamizole and the monitoring of…
17. 3. 2020 Source: Analgesia
Žena kašle

Spiolto Respimat System –⁠ Innovation for Easier Inhalation

Inhalation delivery is the most preferred method of drug administration in chronic obstructive pulmonary disease and bronchial asthma. The effectiveness of therapy is also conditioned by the correct…
16. 3. 2020 Source: COPD

Prognostic Significance of Subclinical Joint Changes on MRI in Hemophilia

Experience shows that monitoring joint changes, especially subclinical ones, is very necessary in the care of hemophiliacs. Unfortunately, conventional X-rays cannot detect early changes in joints.…
16. 3. 2020 Source: Hemophilia

Safety and Tolerance of Metamizole in Postoperative Analgesia in Children

Due to the potential serious side effects of metamizole, the use of this drug in children is often a topic of discussion. Therefore, a prospective multicenter observational non-interventional…
16. 3. 2020 Source: Analgesia
jednotka_intenzivni_pece_jip

Type of Pharmacological Thromboprophylaxis and Disease Stage as Risk Factors for Bleeding in Patients After Colorectal Cancer Surgery

Japanese authors of a study published last year in the World Journal of Surgical Oncology attempted to answer the question of whether the incidence of postoperative bleeding in patients undergoing…
14. 3. 2020 Source: Thromboprophylaxis
Zdravotní sestřička si zapisuje do dokumentace

European Survey on Prophylactic Treatment of Chemotherapy-Induced Nausea and Vomiting Suggests Gaps in Practice and Ways to Improve

Using recommended guidelines for antiemetic prophylaxis can prevent chemotherapy-induced nausea and vomiting (CINV). Nurses play a significant role in administering prophylactic treatment for CINV.…
13. 3. 2020 Source: Antiemetic Therapy
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