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Efficacy and Safety of Gene Therapy Using Adeno-Associated Virus Vector in Patients with Choroideremia

27. 3. 2020 Source: Glaucoma

Choroideremia (CHM) is a rare genetically conditioned retinal disease caused by mutations in the CHM gene, leading to a lack of production of the protein REP1 (ras-associated binding escort protein 1). Currently, there is no approved treatment for CHM. The aim of the study (Tübingen Choroideremia Gene Therapy) published last year in the journal JAMA Ophthalmology was to evaluate the safety and efficacy of subretinally applied gene therapy using an adeno-associated virus vector (AAV2), designed to deliver a functional copy of the CHM gene to…

Results of ATTUNE Total Knee Replacement Implantation –⁠ Data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man

The ATTUNE knee replacement system was fully introduced into clinical practice in 2013. Since then, tens of thousands of implants have been administered to patients worldwide. The mid-term results…

26. 3. 2020 Source: Large Joints

Young man with nephrotic syndrome and portal vein thrombus successfully treated with edoxaban −⁠ case report

Venous thrombosis is one of the main complications of nephrotic syndrome (NS), though it is most often located in the renal vein. The following case report describes an adult patient with relapsing…

26. 3. 2020 Source: Atrial Fibrillation

Options of Anticoagulant Therapy During Pregnancy: Focus on Fondaparinux

The use of most medicinal products is limited during pregnancy either by known teratogenic effects or by lack of safety data for the mother and fetus. A systematic review by authors from the…

24. 3. 2020 Source: Management of Thrombosis in Women

Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?

Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis published in the journal Pharmacopsychiatry in September 2019 examines the effect of the combination of…

20. 3. 2020 Source: Geriatric Patient

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Importance of pH in Care for Stoma Patients

Maintaining good quality peristomal skin and preventing complications related to the stoma site are integral parts of comprehensive care for patients with stomas. The pH of the skin also plays an…

19. 3. 2020 Source: Ostomy

Combination of SGLT2 inhibitors with metformin in terms of mechanism of action

In the treatment of type 2 diabetes (T2D), metformin is recommended as the first-line drug alongside lifestyle modification. However, with disease progression, monotherapy is often insufficient. SGLT2...

18. 3. 2020 Source: Diabetes

Immunotolerance is still the goal of management of hemophilia A with inhibitor in the era of non-factor therapy

New molecules in hemophilia therapy have raised many questions, including regarding the significance and need for immune tolerance induction (ITI). Interesting conclusions from the FIT (Future of…

18. 3. 2020 Source: Hemophilia

Basic Information on the Spread and Course of COVID-19 Infection in China: What We Know So Far?

Currently, we are experiencing a worldwide outbreak of COVID-19 infection caused by the SARS-CoV-2 virus, with the first cases identified in December 2019 in Wuhan, China. As of March 18, 2020,…

17. 3. 2020 Source: Anti-Infectives

Rapid Diagnosis of Depression in Primary Care Settings

Depression is one of the most commonly occurring psychiatric disorders encountered in general practitioners' offices. The general public also very often uses the term “depression” to mean “bad mood.”…

17. 3. 2020 Source: Depression and Anxiety

The Link Between Various Sleep Disorders and the Onset of Depression: What Findings Did the Population Study in Denmark Bring?

A Danish population study published in June 2019 examined the link between different types of sleep disorders and the risk of developing depression. Which disorders confirmed this link after…

17. 3. 2020 Source: Depression and Anxiety

Insufficient dosing of enoxaparin is common in patients post-orthopedic surgery and increases the risk of thromboembolic disease

Orthopedic and traumatological procedures involving the pelvis and lower limbs are associated with a significant increase in the risk of thromboembolic disease. Therefore, prophylaxis with…

17. 3. 2020 Source: Thromboprophylaxis

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