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How do IL-17 and IL-23 inhibitors fare in the treatment of psoriasis in direct comparison?

3. 4. 2020 Source: Biological Treatment

A recent study published in the British Journal of Dermatology is only the second paper to provide a direct comparison of the efficacy and onset speed of treatment with IL-17 and IL-23 inhibitors in patients with moderate to severe plaque psoriasis. The authors monitored the early response to treatment (at week 12), and the efficacy and safety of ixekizumab and guselkumab.

medicína_konzultace_lékař_pacient_prohlídka_karta

Index of Prostate Health as a Predictive Biomarker of Biopsy Outcome

As demonstrated by Spanish authors in their work published at the beginning of 2018, the Prostate Health Index (PHI) is a biomarker that can refine the prediction of prostate biopsy outcomes in men…
2. 4. 2020 Source: Prostate Health Index
muz_bezec_beh_sport

Reference Intervals of Prostate Health Index (PHI) in Healthy Men

For more specific prostate cancer screening, apart from prostate-specific antigen (PSA), its free fraction (fPSA) and one of its precursors, [-2]proPSA (p2PSA), are used today. From these parameters,…
2. 4. 2020 Source: Prostate Health Index
:IMPORT-RN:

Impact of Smoking on Postoperative Wound Healing

Modern surgery aims to shorten postoperative hospitalization by providing faster recovery from surgical consequences. Due to principles of asepsis and antisepsis, wound healing has significantly improved...
1. 4. 2020 Source: Wound Healing

Current Options and Prospects for Effective Antiemetic Treatment in an Effort to Increase Adherence of Oncological Patients to Chemotherapy

Chemotherapy-induced nausea and vomiting (CINV) is strongly associated with treatment in the minds of many oncology patients, and its occurrence is rated as one of the most dreaded and stressful…
31. 3. 2020 Source: Antiemetic Therapy
medicína_konzultace_lékař_pacient_prohlídka_karta

Patient Evaluation of Durvalumab Treatment Results

The interim analysis results of the PACIFIC study, which monitored the efficacy of durvalumab in the treatment of locally advanced unresectable non-small cell lung cancer (NSCLC), demonstrated a…
31. 3. 2020 Source: Lung Cancer
Starší žena má zdeformované ruce kvůli revmatoidní artritidě

Therapy Change from Adalimumab to Baricitinib in Patients with Rheumatoid Arthritis

The aim of the presented analysis of data from the RA-BEAM study was to evaluate the clinical response of patients who were switched to baricitinib during the study due to an inadequate response to…
30. 3. 2020 Source: Biological Treatment

Mechanisms Connecting Diabetes Mellitus and Obesity

Obesity has a close relationship with insulin resistance and diabetes mellitus (DM); weight gain is associated with a higher incidence of both type 1 and type 2 DM. In the development of type 2 DM, depletion...
29. 3. 2020 Source: Diabetes
frustrace_muž_medicína_bolest_hlava

Venotonics in Hemorrhoid Therapy –⁠ Results of a Systematic Review

Hemorrhoids are among the most common pathological findings in the anorectal area, and their incidence increases with age. Various modalities are used in the treatment of this condition, which has…
27. 3. 2020 Source: Venous Insufficiency
žena_nohy_stůl_kancelář_práce_bolest_křečové žíly

Diosmin and its application in the treatment of venous insufficiency

A number of procedures, including pharmacotherapy, are used in the treatment of chronic venous insufficiency, in which diosmin, for example, is applied. The report by pharmacologist MUDr. Jiří Slíva,…
27. 3. 2020 Source: Venous Insufficiency
medicína_dna_genetika_biologie_chromosomy_mikrobiologie_molekula_spirála

Efficacy and Safety of Gene Therapy Using Adeno-Associated Virus Vector in Patients with Choroideremia

Choroideremia (CHM) is a rare genetically conditioned retinal disease caused by mutations in the CHM gene, leading to a lack of production of the protein REP1 (ras-associated binding escort protein…
27. 3. 2020 Source: Glaucoma
operace_kolene

Results of ATTUNE Total Knee Replacement Implantation –⁠ Data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man

The ATTUNE knee replacement system was fully introduced into clinical practice in 2013. Since then, tens of thousands of implants have been administered to patients worldwide. The mid-term results…
26. 3. 2020 Source: Large Joints
Trombóza portální žíly

Young man with nephrotic syndrome and portal vein thrombus successfully treated with edoxaban −⁠ case report

Venous thrombosis is one of the main complications of nephrotic syndrome (NS), though it is most often located in the renal vein. The following case report describes an adult patient with relapsing…
26. 3. 2020 Source: Atrial Fibrillation
medicína_žena_těhotná_těhotenství_matka

Options of Anticoagulant Therapy During Pregnancy: Focus on Fondaparinux

The use of most medicinal products is limited during pregnancy either by known teratogenic effects or by lack of safety data for the mother and fetus. A systematic review by authors from the…
24. 3. 2020 Source: Management of Thrombosis in Women
medicina_senior_deprese

Alternative to benzodiazepines or clomethiazole in the treatment of alcohol withdrawal syndrome?

Alcohol withdrawal syndrome (AWS) is a potentially life-threatening condition. A meta-analysis published in the journal Pharmacopsychiatry in September 2019 examines the effect of the combination of…
20. 3. 2020 Source: Geriatric Patient
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