METHODS OF NON-INVASIVE DIAGNOSTICS AND MONITORING OF URINARY BLADDER CANCER
Authors:
V. Vít; D. Pacík
Authors‘ workplace:
Urologická klinika FN Brno
Published in:
Urol List 2011; 9(3): 7-14
Overview
Initial treatment of urothelial carcinoma (TCC) is associated with high rate of disease recurrence andtendency to progression when recurring. TCC prevalence appears to be more significant (than disease incidence) due to the high rate of superficial lesions recurrence. Patients with TCC thus require careful and long-term monitoring. Currently the standard monitoring process includes cystoscopy, which is an invasive, time consuming and cost ineffective method, often very unpleasant for the patient. The author in his article deals with current methods of non-invasive diagnostics and monitoring of TCC patients from the point of view of replacing cystoscopy with other methods or prolonging the intervals between individual cystoscopy sessions. The author also evaluates available outcomes of the individual tests (sensitivity, specifity) enabling urothelial tumours detection based on urine analysis. The test includes detection of tumour specific antigens in urine, antigens on the surface of cell elements in urine or detection of genetic abnormalities on the subcellular level. In the final section the author describes his own experience with fluorescence hybridization in situ.
Key words:
urothelial carcinoma, non-invasive diagnostics, tumour markers
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Paediatric urologist UrologyArticle was published in
Urological Journal
2011 Issue 3
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