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Cancer treatment induced bone loss (CTIBL): burning issue in prostate cancer patients – our experience


Authors: Prof. MUDr. Dalibor Pacík, CSc. 1;  as. MUDr. Vítězslav Vít 1;  prim. MUDr. Jana Katolická, Ph.D. 2;  RNDr. Jiří Jarkovský, Ph.D. 3
Authors‘ workplace: Urologická klinika LF MU, FN Brno 1;  Onkologicko-chirurgické oddělení, FN u sv. Anny Brno 2;  Institut biostatistiky a analýz, MU Brno 3
Published in: Urol List 2011; 9(1): 60-64

Overview

Androgen deprivation therapy (ADT) is well established in locally advanced or metastatic prostate cancer patients management. Its contribution to the prognosis of these patients is undisputable; CTIBL as its consequence is discussed in a much lesser extent. Cancer treatment induced bone loss leads ultimately to increased morbidity and mortality as well as to increased societal costs. We investigated the presence of osteoporosis and osteopenia based on bone mineral density measurement at DXA in a group of

104 patients at our clinic. The following article presents our data and considers new treatment option for patients suffering from CTIBL presented by a new monoclonal antibody denosumab.

Key words:
androgen deprivation therapy (ADT), BMD, RANKL, denosumab, prostate cancer, pathological fractures


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