Current experience with treatment of prognostically unfavourable acute myeloid leukaemias with CPX-351 at the Institute of Haematology and Blood Transfusion

Overview

The therapeutic agent CPX-351, Vyxeos liposomal, is a newly approved drug intended for therapy of high-risk subtypes of acute myeloid leukaemia (AML) such as AML arising from antecedent myelodysplastic syndrome or associated with previous anticancer therapy. In the Czech Republic, CPX-351 is reimbursed for patients aged 60 and over with the above-mentioned AML subtypes. The following paper describes the indication and dosage schedule of CPX-351, its mechanism of action and also briefly mentions the therapeutic results and safety profile of CPX-351 according to the product registration study. The article then focuses on current clinical experience with CPX-351 since 2022 at the UHKT Prague and analyses in detail the case reports of two patients treated at the UHKT in the last months. CPX-351 therapy represents, according to our experience so far, a relatively effective option for treating high-risk AML in which treatment with standard chemotherapy often fails.

Keywords:

acute myeloid leukaemia – myelodysplastic syndrome – CPX-351 – therapy-related AML