Therapy targeting CD19 antigen in diffuse large B-cell lymphoma

Czech version

Authors: Viktor Procházka ¹; V. Hanáčková ¹; L. Henzlová ²; P. Flodr ³; T. Papajík ¹
Authors‘ workplace: Hemato-onkologická klinika LF UP a FN Olomouc ¹; Klinika nukleární medicíny LF UP a FN Olomouc ²; Ústav klinické a molekulární patologie, LF UP a FN Olomouc ³
Published in: Transfuze Hematol. dnes,30, 2024, No. 1, p. 13-25.
Category: Review/Educational Papers
doi: https://doi.org/10.48095/cctahd2024prolekare.cz2

Overview

Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma in the Czech Republic. It represents a very heterogeneous group of aggressive tumors with diverse biology, and varied clinical manifestations. The standard of therapy is based on immunotherapy targeted against the CD20 antigen of the tumor cells. The combination of the monoclonal antibody rituximab with chemotherapy has historically demonstrated a major benefit of cytotoxic immunity mechanisms in patients. This therapeutic concept, which has historically led to cure in nearly two-thirds of patients, has encountered its limits. Research into alternative immunotherapy approaches has led to the introduction of a generationally successful new class of drugs targeting the CD19 antigen with different mechanisms of action ranging from simple antibody action (tafasitamab) to antibody-drug conjugate (ADC) administration (loncastuximab-tesirine), to the formation of sophisticated CAR-T lymphocyte chimeric constructs (axicabtagene ciloleucel, tisagenlecleucel and lisocabtagene maraleucel). The review aims to summarize the findings of advanced medical research of new molecules, their sequences, and combinations with implications for therapeutic practice in the Czech Republic.

Keywords:

immunotherapy – Monoclonal antibodies – CD19 antigen – diff use large B-cell lymphoma

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Autoři děkují MUDr. Lence Henzlové, Ph.D, za přípravu obrazových podkladů vyšetření PET/CT a MUDr. Patriku Flodrovi, Ph.D., za přípravu fotodokumentace histologických preparátů.

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Do redakce doručeno dne: 4. 1. 2024.
Přijato po recenzi dne: 24. 1. 2024.

prof. MUDr. Vít Procházka, Ph.D.
Hemato-onkologická klinika
LF UP a FN Olomouc
Zdravotníků 248/7
779 00 Olomouc
e-mail: vit.prochazka@fnol.cz