Current options of ivosidenib in acute myeloid leukemia
Authors:
M. Čerňan; T. Szotkowski
Authors‘ workplace:
Hemato-onkologická klinika LF UP a FN Olomouc
Published in:
Transfuze Hematol. dnes,30, 2024, No. 1, p. 7-12.
Category:
Review/Educational Papers
doi:
https://doi.org/10.48095/cctahd2024prolekare.cz1
Overview
Acute myeloid leukemia is the most common type of acute leukemia in adults. The long-term treatment results remain unsatisfactory for the majority of patients. Ongoing research into the process of malignant transformation of the hematopoietic stem cells has revealed new mutations that represent attractive targets for modern drugs. Ivosidenib, an inhibitor of mutated isocitrate dehydrogenase 1 (IDH1), has shown encouraging results in combination with azacitidine in patients with previously untreated acute myeloid leukemia with an IDH1 mutation. The review discusses the current possibilities of using ivosidenib in patients with acute myeloid leukemia in the Czech Republic.
Keywords:
Acute myeloid leukemia – ivosidenib – azacitidine – isocitrate dehydrogenase – IDH1
Sources
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PODÍL AUTORŮ NA RUKOPISU
MČ – hlavní autor, sepsání první a finální verze manuskriptu
TS – spoluautor, kritická revize rukopisu
PROHLÁŠENÍ
Autor MČ deklaruje konzultační činnost pro společnost Servier, konzultační činnost a cestovní granty od společnosti AbbVie. Autor TS nedeklaruje konflikt zájmů.
DEDIKACE
Práce byla podpořena MZ ČR – RVO (FNOL, 00098892) a IGA_LF_UP_2023_005.
Do redakce doručeno dne: 16. 12. 2023.
Přijato po recenzi dne: 29. 1. 2024.
MUDr. Martin Čerňan, Ph.D.
Hemato-onkologická klinika
LF UP a FN Olomouc
Zdravotníků 248/7
77 900 Olomouc
e-mail: martin.cernan@fnol.cz
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
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