Blood cell storage lesion
Authors:
R. Procházková
Authors‘ workplace:
Transfuzní oddělení, Krajská nemocnice Liberec a Ústav zdravotnických studií, Technická univerzita v Liberci
Published in:
Transfuze Hematol. dnes,19, 2013, No. 4, p. 240-243.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
Blood cells are subjected to important morphologic and biochemical changes during collection, processing and storage. Their structure and function are influenced by a number of factors, such as collection technique, composition of coagulation solution, contact with the surface of the collection bag or set, method of processing and content of leukocytes in the product or leukodepletion method. Metabolic and morphologic alterations in red blood cells and platelets concentrates limit their storage and may be associated with delayed posttransfusion recovery in vivo.
The communication provides a brief summary of changes in blood cells during storage, the possibitity to monitor cell injury and summarizes the significance of markers of cell injury research, validation of new procedures and practice.
Key words:
blood cells, cell injury, markers, activation
Sources
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Labels
Haematology Internal medicine Clinical oncologyArticle was published in
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