Acquired thrombophilias as a cause of early pregnancy losses
Authors:
M. Simonidesová 1; J. Šimko 2; M. Martišová 3; K. Holomáň 4
Authors‘ workplace:
Gynekologicko-pôrodnícke oddelenie NsP Považská Bystrica
1; Gendiagnostica Bratislava s. r. o., Laboratórium molekulárnej biológie
2; Klinika hematológie a transfuziológie SZU, LFUK a UNB Bratislava
3; II. Gynekologicko-pôrodnícka klinika LFUK a UNB Bratislava
4
Published in:
Transfuze Hematol. dnes,19, 2013, No. 3, p. 171-179.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
Acquired thrombophilias are one of the causes of early miscarriages. The basis of these early pregnancy losses lies not in their thrombogenic potential, but in their ability to induce failure of implantation, placentation or embryonic development. Antiphospholipid syndrome is the most frequent acquired thrombophilia in pregnancy. Due to their pro-thrombotic potential, BCR/ABL negative myeloproliferative neoplasms, polycythemia vera and essential thrombocythemia, may be included in a wider group of acquired thrombophilic states. Their occurrence is rare in pregnancy, but it is relatively frequently associated with unfavourable outcomes of pregnancy and higher maternal complications. The authors offer a summary of basic knowledge relating to these nosological entities and an overview of literature regarding the relationship between acquired thrombophillic states and early pregnancy loss.
Key words:
acquired thrombophilia, antiphospholipid syndrome, polycythemia vera, essential thrombocythemia, miscarriage
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Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
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