Bone marrow microenvironment and its role in the pathogenesis of leukaemia

Czech version

Authors: E. Létalová ¹; M. Doubek ²; F. Folber ¹; J. Verner ¹; M. Mráz ²; Š. Pospíšilová ²; J. Mayer ²
Authors‘ workplace: Interní hematoonkologická klinika, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity, Brno ¹; Středoevropský technologický institut, Masarykova univerzita, Brno ²
Published in: Transfuze Hematol. dnes,17, 2011, No. 4, p. 171-176.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Bone marrow microenvironment plays a key role in the process of haematopoiesis. It has a supportive function for quiescent haematopoietic stem cells located in so called „niches“. It provides appropriate conditions for haematopoietic stem cell differentiation and for the proliferation of blood elements. Under certain conditions, the bone marrow microenvironment may be colonized by circulating peripheral haematopoietic stem cells (a fact used in the process of peripheral blood stem cell transplantation). It is probable that this mechanism is also used by malignant (leukemic) cells to infiltrate the microenvironment and thus take advantage of all the supportive functions provided to divide, proliferate and more or less differentiate into the leukemic population.

Key words:
haematopoiesis, bone marrow microenvironment, haematopoietic stem cell niche

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