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Úspěšný odběr periferních krvetvorných buněk u pacientky s chronickou myeloidní leukemií léčenou nilotinibem. Kazuistika


Authors: S. Vokurka 1;  D. Lysák 1;  M. Karas 1;  V. Koza 1;  P. Dvořák 2;  M. Hrabětová 1;  P. Jindra 1;  V. Vozobulová 1
Authors‘ workplace: Hematologicko-Onkologické oddělení a 2Oddělení lékařské genetiky, Fakultní nemocnice Plzeň 1
Published in: Transfuze Hematol. dnes,16, 2010, No. 2, p. 101-103.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

Here we report a case of successful mobilization and harvest of peripheral hematopoietic stem cells in imatinib pretreated and nilotinib treated 52-years old woman, who was diagnosed with chronic myeloid leukemia, Sokal and Hasford intermediate risk group, in 2002. She failed interferon-alfa and imatinib treatment and achieved first complete molecular remission after 16 months of nilotinib treatment. The patient was mobilized with filgrastim at the dose of 10 μg/kg/day. On the day +4, single leukapheresis was performed and autologous graft containing 2,9 x 106/kg CD34+ cell was harvested. The apheresis product was cryopreserved and analyzed: the RT-PCR analysis revealed BCR-ABL positivity (BCR-ABL/ABL ratio 0,0017 in RQ-PCR), the FISH analysis was negative. To our knowledge, this is the first report of successful PBSC harvest in a patient significantly pretreated with imatinib and nilotinib.

Key words:
nilotinib, apheresis, chronic myeloid leukemia


Sources

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