#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Oxidative stress and ASA resistance in patients withcoronary arthery disease


Authors: J. Prošková 2;  D. Stejskal 1,2;  B. Lačňák 1
Authors‘ workplace: Interní oddělení, Nemocnice Šternberk2Oddělení laboratorní medicíny, Nemocnice Šternberk 1
Published in: Transfuze Hematol. dnes,, 2004, No. 1, p. 25-28.
Category:

Overview

Almost one third of population is affected by thrombocytopathy with platelet hyperaggregability. A lotof these individuals have coronary artery disease (CAD) and are treated with low doses of ASA(acetylsalicylic acid). Recent papers often report on ASA resistance (ASA-R). In general, ASA resistanceoccurs in 5–15% of population. Several communications reported the data on 70–80% of ASA resistancein persons with progressed ICH. Many factors account for it: smoking, NSA abuse, polymorphisms COXand IIb–IIIa, DM, dyslipidemia, stress, etc. A direct correlation between oxidative stress and theincidence of ASA-R (elevated synthesis of isopropanes with aggregation effect) is assumed. The aim ofthe present communication was to study a correlation between ASA resistance and oxidative stress inCAD patients. Methods: The study was performed with 298 individuals treated with 100 mg of ASA/dayunder the secondary prevention programme. The spontaneous platelet aggregability was examined aswell as aggregability after induction CPG (cut-off for ASA-R spontaneous aggregability – 5%, CPG slope– 53%/min), AOPP and ultrasensitive CRP were determined. Results: 298 individuals (65% men, 35%women, mean age 64.8±9.8 years), secondary CAD prevention. ASA resistance was found in 43%, AOPPvalues was significantly increased in 13% (>100 µmol/l). No correlation was found between aggregationmarkers and AOPP/CRP concentration (even after stratification according to ASA-R). The incidence ofASA resistance correlated only with age (correlation coefficient 0.19, p < 0.0001). AOPP and CRP valueswere higher in men compared with women (94.2 µmol/l vs. 77.7 µmol/l, p < 0.05; 12.9 mg/l vs. 6.6 mg/l, p

Key words:
ASA resistance, oxidative stress, advanced oxidation protein products (AOPP)

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Haematology Internal medicine Clinical oncology
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#