Significance of the TPS Cytokeratin Marker in the Postoperative Follow Up of Colorectal Carcinoma Patients

Czech version

Authors: K. Rupert; L. Holubec ^*; J. Nosek; K. Houdek; Topolčan O.#; V. Třeška
Authors‘ workplace: Chirurgická klinika FN Plzeň, prof. MUDr. V. Třeška, DrSc. ; Radioterapeutické a onkologické oddělení FN Plzeň, doc. MUDr. J. Fínek, Ph. D. #Oddělení nukleární medicíny, prof. MUDr. O. Topolčan, CSc. ^*
Published in: Rozhl. Chir., 2009, roč. 88, č. 8, s. 428-433.
Category: Monothematic special - Original

Overview

Aim:
Examination of tumour markers conducive to follow up of the patients with colorectal carcinoma.

Material and Methods:
The tumour markers were examined in the population of patients with primarily established and histologically verified colorectal adenocarcinoma.

Results:
The resection therapy resulted in the decrease in post-operative CEA levels. There were no changes in pre- and post-operative CA 19-9 levels; unlike with post-operative TPS levels having been significantly increased, probably due to reparation processes resulting from the surgery. It can be concluded that pre- and post-operative CEA levels are the most suitable markers to check the effect of surgery. With a 95%-specificity for the establishment of recidives, the highest sensitivity was reached with TPS (83%); the sensitivities of the classical tumour markers CEA and CA 19-9 were significantly lower (41% and 25%, respectively). The results should be interpreted with caution due to a small number of relapses regarding a short follow up and rather local-regional character of the recidives.

Conclusion:
However, TPS seems to be a promising marker for the follow up of the patients with colorectal carcinoma. Thus, an ideal combination seems to be that of CEA and TPS.

Key words:
colorectal carcinoma – tumour markers – CEA – CA 19-9 – TPS

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