Night shifts and tumorous diseases – basic information
Authors:
M. Křibská; M. Nakládalová
Authors‘ workplace:
Klinika pracovního lékařství LF UP a FN Olomouc
přednostka doc. MUDr. Marie Nakládalová, PhD.
Published in:
Pracov. Lék., 69, 2017, No. 1-2, s. 22-26.
Category:
Review Article
*Práce byla publikována ve formě posteru na X. Martinských dnech verejného zdravotníctva ve dnech 15.–17. března 2017.
Overview
In 2010 International Agency for Research on Cancer (IARC) included work in night shifts in the category 2A, indicating that work in night shifts which is connected with circadian disorder is a probable human carcinogen. This communication, based on analysis of available literature, intended to analyze the influence of work with a share in night shifts in view of neoplastic diseases.
The literature search for obtaining relevant scientific studies in English has been performed with the use of common internet databases.
The evidence, which should confirm considerations about carcinogenesis induced by work in shifts, may be divided in two basic areas. Art first the case is the disorder of circadian rhythm caused by light during night and connected with the change of sleeping activity, which may result in suppression of melatonin and changes in (expression of) circadian genes. Sleep deprivation is another mechanism. Most studies describe a higher risk of breast cancer in the shift night work and some studies describe a higher risk of prostate cancer¸ colon cancer and endometrial cancer. These alarming observations lead to the search of effective preventive measures.
Keywords:
night work – work in shifts – circadian rhythms – tumors
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Hygiene and epidemiology Hyperbaric medicine Occupational medicineArticle was published in
Occupational Medicine
2017 Issue 1-2
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