#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
CS
proLékaře.cz / Journals / Nuclear Medicine / 2022 - 2

Multimodal magnetic nanomaterials for diagnostics and therapy

Czech version

Authors: Martin Vlk 1,2;  Veronika Valová 1,2;  Matěj Štíbr 1;  Zuzana Sobkuliaková 1;  Ján Kozempel 1
Authors‘ workplace: Katedra jaderné chemie, Fakulta jaderná a fyzikálně inženýrská, České vysoké učení technické v Praze 1;  Klinika nukleární medicíny a endokrinologie, Fakultní nemocnice v Motole, Praha, ČR 2
Published in: NuklMed 2022;11:22-31
Category: Review Article

Overview

Aim: Application of magnetic nanoparticles as multimodal materials for current diagnostics and therapy.

Introduction: Rapid developments in nanotechnology have facilitated the emergence of new nanomaterials. This trend is also associated with an increased interest in nano and micro systems consisting of magnetic carriers. By combining a magnetic vector with a biologically active substance, unique properties can be achieved which can be used in many areas of biotechnology and medicine. Issues description: The most common materials are magnetic nanoparticles synthesised of iron oxides. Currently, widely studied are superparamagnetic iron oxide nanoparticles, socalled SPIONs, which below a certain size range (1–20 nm) exhibit a single-domain character, which causes a phenomenon called superparamagnetism. In addition to particle size, surface properties are important. The surface size (in the order of 100 m2/g) allows its modification, which increases the biocompatibility of particles and reduces toxicity. Magnetic nanoparticles have considerable potential for use in biomedical applications, especially in the field of teranostics. At present, nanoparticle systems are studied mainly as contrast agents in MR imaging techniques, in positron emission tomography, or the conversion of magnetic energy into thermal energy can be used, which uses a method called hyperthermia. Other uses include separation, cell analysis, or cell labeling, which appear promising in imaging methods.

Conclusion: As shown, the application of magnetic nanoparticles in medicine is extensive. The primary challenge is the synthesis of these nanoparticles, and there are a number of processes that provide nanoparticles with different properties. Due to the nature of nanoparticles, the care must also be taken to stabilize them in order to prevent aggregation, and in the case of their use as carriers, it is also necessary to solve the problem of entrapment of the desired substance. These problems are still the subject of research, but despite these difficulties, magnetic nanoparticles are a potentially powerful tool for current diagnostics and therapy.

Keywords:

SPIONs – megnetism – hyperthermy

Sources
  1. Psimadas D, Baldi G, Ravagli C, et al. Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe2O4 and Fe3O4 metal cores. Nanotechnology. 2014; 25: 025101
  2. Lu AH, Salabas EL, Schuth F. Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application. Angew Chem Int Ed. 2007; 46: 1222–1244
  3. Lima-Tenório MK, Pineda EA, Ahmad NM, et al. Magnetic nanoparticles: In vivo cancer diagnosis and therapy. Int J Pharm. 2015; 493: 313–327
  4. Ramimoghadam D, Bagheri S, Hamid SBA. Progress in electrochemical synthesis of magnetic iron oxide nanoparticles. J Magn Magn Mater. 2014; 368: 207–229
  5. Babes L, Denizot B, Tanguy G, et al. Synthesis of Iron Oxide Nanoparticles used as MRI contrast agents: A Parametric study. J Colloid Interface Sci. 1999; 212: 474-482
  6. Mahdavi M, Ahmad MB, Haron MJ, et al. Synthesis, Surface Modification and Characterisation of Biocompatible Magnetic Iron Oxide Nanoparticles for Biomedical Applications. Molecules 2013; 18: 7533-7548
  7. Laurent S, Forge D, Port M, et al. Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev. 2008; 108: 2064-2110
  8. Wu W, He Q, Jiang C. Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies. Nanoscale Res Lett. 2008; 3: 397-415
  9. Jana NR, Chen Y, Peng X. Size-and Shape-Controlled Magnetic (Cr, Mn, Fe, Co, Ni) Oxide Nanocrystals via a Simple and General Approach. Chem Mater. 2004; 16: 3931-3935
  10. Lassenberger A, Grünewald TA, van Oostrum PDJ, et al. Monodisperse Iron Oxide Nanoparticles by Thermal Decomposition: Elucidating Particle Formation by Second-Resolved in Situ Small-Angle X-ray Scattering. Chem Mater. 2017; 29: 4511-4522
  11. Kohler N, Fryxell GE, Zhang M. A Bifunctional Poly(ethylenegylcol) Silane Immobilized on Metallic Oxide-Based Nanoparticles for Conjugation with Cell Targeting Agents. J Am Chem Soc. 2004; 126: 7206-7211
  12. Lee Y, Lee J, Bae CJ, et al. Large-Scale Synthesis of Uniform and Crystalline Magnetite Nanoparticles Using Reverse Micelles as Nanoreactors under Reflux Conditions. Adv Funct Mater. 2005; 15: 503-509
  13. Wu W, Wu Z, Yu T, et al. Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications. Sci Technol Adv Mater. 2015; 16: 2
  14. Xiao L, Li J, Brougham DF, et al. Water-Soluble Superparamagnetic Magnetite Nanoparicles with Biocompatible Coating for Enhanced Magnetic Resonance Imagining. ACS Nano. 2011; 5: 6315-6324
  15. Fernandéz-Barahona I, Muñoz-Hernando M, Herranz F. Microwave-Driven Synthesis of Iron-Oxide Nanoparticles for Molecular Imaging. Molecules. 2019; 24:1224
  16. Wang WW, Zhu YJ, Ruan ML. Microwave-assisted synthesis and magnetic property of magnetite and hematite nanoparticles. J Nanopart Res. 2007; 9: 419-426
  17. Mahmoudi M, Sant S, Wang B, et al. Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy. Adv Drug Deliv Rev. 2011; 63: 24–46
  18. Lewinsky N, Colvin V, Drezek R. Cytotoxicity of nanoparticles. Small 2008; 4: 26-49
  19. Khalkhali M, Sadighian S, Rostamizadeh K, et al. Synthesis and characterization of dextran coated magnetite nanoparticles for diagnostics and therapy. Bioimpacts. 2015; 5: 141-150
  20. Turcheniuk K, Tarasevich AV, Kukhar VP, et al. Recent advances in surface chemistry strategies for the fabrication of functional iron oxide based magnetic nanoparticles. Nanoscale. 2013; 5: 10729-10752
  21. Veiseh O, Gunn JW, Zhang M. Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev. 2010; 62: 284-304
  22. Deng YH, Wanch CC, Hu JH, et al. Investigation of formation of silica-coated magnetite nanoparticles via sol-gel approach. Colloids Surf A: Physiochem Eng Asp. 2005; 262: 87-93
  23. Yoo D, Lee JH, Shin TH, Cheon J. Theranostic magnetic nanoparticles. Acc Chem Res. 2011; 44: 863–874
  24. Yu MK, Park J, John S. Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics. 2012; 2: 3-44
  25. Unsoy G, Khodadust R, Yalcin S, et al. Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery. Eur J Pharm Sci. 2014; 62: 243-250
  26. Enochs WS, Schaffer B, Bhide PG, et al. MR Imaging of slow axonal transport in vivo. Exp Neurol 1993; 123: 235-24
  27. Lin MM, Kim DK, Haj AJE, Dobson J. Development of Superparamagnetic Iron Oxide nanoparticles (SPIONs) for translation to clinical applications. IEEE Trans Nanobioscience. 2008; 7: 298-305
  28. Santhosh PB, Ulrich NP. Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics. Cancer Lett. 2013; 336: 8-17
  29. Aghanejad A, Jalilian AR, Maus S, et al. Optimized production and quality control of 68Ga-DOTATATE. Iran J Nucl Med. 2016; 24: 29-36
  30. Rosales RTM, Tavar R, Paul RL, et al. Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET–MRI Agent. Angew Chem Int Ed. 2011;50:5509 –5513
  31. Choi JS, Park JC, Nah H, et al. A hybrid nanoparticle probe for dual-modality positron emission tomography and magnetic resonance imaging. Angew Chem Int Ed Engl. 2008; 47: 6259-6262.
  32. Hong H, Zhang Y, Sun J, et al. Molecular imaging and therapy of cancer with radiolabeled nanoparticles. Nano Today. 2009; 4: 399-413
  33. Lee HY, Li Z, Chen K, et al. PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J Nucl Med. 2008; 49:1371-1379
  34. Sun Z, Cheng K, Wu F, et al. Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging. Nanoscale. 2016; 8:19644–19653
  35. Breeman WA, Jong de M, Blois de E, et al. Radiolabelling DOTA-peptides with 68Ga. Eur J Nucl Med Mol Imaging. 2005; 32: 478-485
  36. Riss PJ, Kroll C, Nagel V, Rosch F. NODAPA-OH AND NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. Bioorg Med Chem Lett. 2008; 18: 5364-5367
  37. Madru R, Tran TA, Axelsson J, et al. 68Ga-labeled superparamagnetic iron oxide nanoparticles (SPIONs) for multi-modality PET/MR/Cherenkov luminescence imaging of sentinel lymph nodes. Am J Nucl Med Mol Imaging. 2014; 4: 60-69
  38. Barahona IF, Hernando MM, Pellico J, et al. Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles. Appl Sci. 2018; 8: 1098
  39. Fernandéz-Barahona I, Ruiz-Cabello J, Herranz F, Pellico J. Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging. J Vis Exp. 2018; 141
  40. Same S, Aghanejad A, Nakhjavani SA, et al. Radiolabeled theranostics: magnetic and gold nanoparticles. Bioimpacts. 2016; 6: 169-181
  41. Salvanou E, Bouziotis P, Tsoukalas C. Radiolabeled Nanoparticles in Nuclear Oncology. Adv Nan Res. 2018; 1: 38-55
  42. Madru R, Kjellman P, Olsson F, et al. 99mTc-Labeled Superparamagnetic Iron Oxide Nanoparticles for Multimodality SPECT/MRI of Sentinel Lymph Nodes. J Nucl Med. 2012; 53: 459–463
  43. Gholami A, Mousavie Anijdan SH. Development of 153Sm-DTPA-SPION as a theranostic dual contrast agents in SPECT/MRI. Iran J Basic Med Sci. 2016; 19: 1056–1062
  44. Henriksen G, Breistol K, Bruland ØS, et al. Significant Antitumor Effect from Bone-seeking, α-Particle-emitting 223Ra Demonstrated in an Experimental Skeletal Metastases Model. Cancer Res. 2002; 62: 3120
  45. Kozempel J. Vlk M. Nanoconstructs in Targeted Alpha-Therapy. Recent Pat  Nanomed. 2014; 4: 71-76
  46. Kozempel J, Mokhodoeva O, Vlk M. Progress in Targeted Alpha-Particle Therapy. What We Learned about Recoils Release from In Vivo Generators. Molecules. 2018; 23: 581
  47. Mokhodoeva O, Vlk M, Málková E, et al. Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs. J Nanopart Res. 2016; 301: 1-12
  48. Liang S, Wang Y, Yu J, et al. Surface modified superparamagnetic iron oxide nanoparticles: As a new carrier for biomagnetically targeted therapy. J Mater Sci Mater Med. 2007; 18: 2297-2302
  49. Radovic M, Calatayud MP, Goya GF, et a. Preparation and in vivo evaluation of multifunctional 90Y-labeled magnetic nanoparticles designed for cancer therapy. J Biomed Mater Res A 2014; 103: 126-134
  50. Dash A, Pillai MRA, Knapp FF. Productionof 177Lu for Targeted Radionuclide Therapy: Available Options. Nucl Med Mol Imaging. 2015; 49: 85-107
  51. Ognjanović M, Radović M, Mirković M, et al. 99mTc-, 90Y-, and 177Lu-Labeled Iron Oxide Nanoflowers Designed for Potential Use in Dual Magnetic Hyperthermia/Radionuclide Cancer Therapy and Diagnosis. ACS Appl Mater Interfaces. 2019; 11: 41109-41117
  52. Nosrati S, Shanehsazzadeh S, Yousefnia H. Biodistribution evaluation of 166Ho–DTPA–SPION in normal rats. J Radioanal Nucl Chem. 2015; 307: 1559-1566
Labels
Nuclear medicine Radiodiagnostics Radiotherapy
Editorial
Lymphoscintigraphy in diabetic – case report
Klinika nukleární medicíny 3. LF UK a FN Královské Vinohrady v Praze
Historický kvíz
Sonda do historie
10. Konference radiologické fyziky, Přerov
Spolupráce na přípravě nejslibnějšího zářiče alfa pro léčbu nádorových onemocnění
Slavnostní přednáška prof. Ing. Ondřeje Lebedy, Ph.D.
Article was published in

Nuclear Medicine

Issue 2
2022 Issue 2
Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#