Hyperlipoprotienemias and (not only) atherosclerosis: fragments from history and present
Authors:
Richard Češka
Authors‘ workplace:
Centrum preventivní kardiologie, 3. interní klinika 1. LF UK a VFN v Praze
Published in:
Čas. Lék. čes. 2017; 156: 303-307
Category:
Review Articles
Overview
The examples from the history, as well as the recent view, clearly demonstrate a great change in the perception of hyperlipoprotienemias and dyslipidemias (HLP and DLP) at the end of 20th and at the beginning of 21st century. Our aim is not a complex overview about HLP and DLP. We just want to describe the changing position and importance of these diseases in clinical medicine. We will touch cardiology, angiology, but also diabetology, hepatology and gastroenterology (pancreas).
HLP and DLP, which started as a research topic in laboratory became clinically interesting as risk factors of atherosclerosis. They are understood as epidemic occurrence diseases, also in connection with metabolic syndrome. However, some of them, e.g. familial chylomicronemia or homozygous familial hypercholesterolemia fulfill criteria of rare diseases.
Keywords:
hyperlipoproteinemia, dyslipidemia, atherosclerosis, statins, PCSK9-inhibitors, familial hypercholesterolemia, familial chylomicronemia
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