Structure and function of lymphatic capillaries in synovial joint
Authors:
Emília Rovenská; Jozef Rovenský
Authors‘ workplace:
Národný ústav reumatických chorôb, Piešťany, SR
Published in:
Čas. Lék. čes. 2012; 151: 520-522
Category:
Review Articles
Overview
The review article focuses on the structure and function of lymphatic capillaries in connective tissues of skin, muscles and synovial membrane. Lymphatic capillaries (initial lymphatics) are formed from endothelial cells mutually arranged so that their intercellular junctions have different structure. In one of the different types of intercellular junctions the distal ends of endothelial cells overlap one another in the form of projections. Desmosomes are missing between the cell membranes of the internal and external projection without presence of any other junctional complexes. The external projection of the endothelial cell is tightly attached to the surrounding connective tissue with the help of anchoring filaments. The internal projection of the neighbouring endothelial cell may tilt over to the lumen of the lymphatic capillary and this may result in a several micrometers wide communication between the interstitium and the lumen with efflux of tissue fluid and leukocytes from the interstitium in to the lumen of the capillary. Lymphologists call the above mentioned openable intercellular junctions in their works also endothelial microvalves or primary valves. These primary valves in cooperation with classical (secondary) intralymphatic valves enable one way lymph flow during spontaneous contractions of the initial lymphatics. It is supposed that primary valves in lymphatic capillaries have an important role in the drainage of the connective tissues affected by inflammation also in the synovial joint.
Key words:
synovial joint, lymphatic capillaries, drainage, immune cells.
Sources
1. Davies DV. The lymphatics of the synovial membrane. J Anat 1946; 80: 21–25.
2. Schmidt-Schönbein GW. The second valve system in lymphatics. Lymphat Res Biol 2003; 1(1): 25–29.
3. Ikomi E, Hunt J, Hanna G, et al. Interstitial fluid, plasma protein, colloid, and leukocyte uptake into initial lymphatics. J Cell Physiol 1996; 81: 2060–2067.
4. Trzewick J, Mallipattu SK, Artmann GM, et al. Evidence for a second valve system in lymphatics: endothelial microvalves. FASEB J 2001; 15: 1711–1717.
5. Hauck G. The connective tissue in view of the lymphology. Experientia (Basel) 1982; 38: 1121–1222.
6. Olszewski WL. Interrelationships within the lymphatic system. In: Olszewski WL. Lymph stasis. Pathophysiology, diagnosis and treatment. Bocca Raton: CRC Press 1991; 5–12.
7. Salmi M, Jalkanen S. How do lymphocytes know where to go: current concepts and enigmas of lymphocyte homing. Adv Immunol 1997; 64: 139–218.
8. Hay JB, Young AL. Lymphocyte circulation. In: Reed RK, Bert JL (eds). Interstitium, connective tissue and lymphatics. London: Portland Press, 1995; 245–250.
9. Abernethy NJ, Hay JB. The recirculation of lymphocytes from blood to lymph: physiological considerations and molecular mechanisms. Lymphology 1992; 25: 1–30.
10. Smith JB, McIntosh GB, Morris B. The traffic of cells through tissues: a study of peripheral lymph in sheep. J Anat 1970; 107: 87–100.
11. Gowans JL, Knight EJ. The route of recirculation of lymphocytes in the rat. Proc R Soc B 1964; 159: 257.
12. Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996; 272: 60–66.
13. Hall JG. An essay in lymphocyte circulation and the gut. In: Trnka Z, Cahill RN (eds.). Essays on the anatomy and physiology of lymphoid tissues. Basel, S. Karger 1980; 100–111.
14. Lynch PM, Delano FA, Schmid-Schönbein GW. The primary valves in the initial lymphatics during inflammation. Lymphat Res Biol 2007; 5: 3–10.
15. Angeli V, Randolph GJ. Inflammation, lymphatic function, and dendritic cell migration. Lymphat Res Biol 2006; 4: 217–228.
16. Pulllinger BD, Florey HW. Proliferation of lymphatics in inflammation. J Pathol 1937; 45: 157–170.
17. Kuhns JG. Lymphatic drainage of joints. Arch Surg 1933; 27: 345–391.
18. Olszewski WL. Human afferent lymph contains apoptotic cells and “free” apoptotic DNA fragments – can DNA be reutilised by the lymph node cells? Lymphology 2001; 34: 179–183.
19. Simkin PA. Synovial perfusion and synovial fluid solutes. Ann Rheum Dis 1995; 54: 424–428.
20. Levick JR. A method for estimating macromolecular reflection by human synovium using measurements of intra-articular half lives. Ann Rheum Dis 1998; 57: 339–344.
21. Casley-Smith JB. The structure and functioning of the blood vessels, interstitial tissues, and lymphatics. In: Földi M, Casley-Smith JR. Lymphangiology. New York-Stuttgart: Schattauer 1983; 832.
22. Casley-Smith JB. The structure and functioning of tissue channels and lymphatics. Lymphology 1980; 13: 177–183.
23. Leak LV, Burke JF. Fine structure of the lymphatic capillary and the adjoining connective tissue area. Am J Anat 1966; 118: 785–810.
24. Debes GE, et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nature Rev Immunol 2005; 6: 889–894.
25. Pullinger BD, Florey HW. Some observations on the structure and functions of lymphatics: their behaviour in local oedema. Brit J Exp Pathol 1935; 16: 49–61.
26. Casley-Smith JR. Are initial lymphatics normally pulled open by the anchoring filaments? Lymphology 1980; 13: 120–129.
27. Rovenská E, Rovenský J. Lymphatic vessels: structure and function. IMAJ 2011; 13: 762–768.
28. Ahlquist J. Swelling of synovial joints – An anatomical, physiological and energy metabolical approach. Pathophysiology 2000; 7: 1–19.
29. Jayson MIV, Barks JS. Oedema in rheumatoid arthritis: changes in the coefficient of capillary filtration. Brit Med J 1971; 2: 555–557.
30. Jayson MIV, Cavill I, Barks JS. Lymphatic clearance rates in rheumatoid arthritis. Ann Rheum Dis 1971; 30: 638–639.
31. Olszewski WL, Pazdur J, Kubasiewicz E, et al. Lymph draining from foot joints in rheumatoid arthritis provides insight into local cytokine and chemokine production and transport to lymph nodes. Arthritis Rheum 2001; 44: 541–549.
32. Karkkainen MJ, et al. Molecular regulation of lymphangiogenesis and targets for tissue oedema. Trends Mol Med 2001; 7: 18–22.
33. Szuba A, et al. Therapeutic lymphangiogenesis with human recombinant VEGF-C. FASEB J 2002; 16: 1985–1987.
34. Saaristo A, et al. Vascular endothelial growth factor-C accelerates diabetic wound healing. Amer J Pathol 2006; 169: 1080–1087.
35. Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature 2005; 438: 946–953.
36. Polzer K, Baeten D, Soleiman A, et al. Tumor necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints. Ann Rheum Dis 2008; 67: 1610–1616.
37. Chaitanya GV, Franks SE, Cromer V, et al. Differential cytokine responses in human and mouse lymphatic endothelial cells to cytokines in vitro. Lymph Res Biol 2010; 8: 155–164.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
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