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Endocannabinoid system II – the role in addictive behaviour, depression and in pathology of eating behaviour


Authors: Martykánová L.
Authors‘ workplace: Ústav preventivního lékařství LF MU, Brno
Published in: Čas. Lék. čes. 2010; 149: 368-371
Category: Review Article

Endokanabinoidní systém je součástí neurobiologického mechaniSmu, který je podstatou drogové závislosti u všech známých typů drog včetně nikotinu a alkoholu. Nedávno byla objevena i spojitost endokanabinoidů s biologickou podstatou deprese a poruchami příjmu potravy. Byly objeveny polymorfismy genů kódujících kanabinoidní CB1 receptory a genů kódujících hlavní degradační enzym FAAH, které jsou zodpovědné za vznik patologií v oblasti motivace a nálady.

Overview

Endocannabinoid system is involved in the neurobiological mechanism underlying drug addiction in all known kinds of drugs including nicotine and alcohol. Recently, relationships between endocannabinoids and biological nature of depression and eating disorders were recognised. Polymorphisms of genes encoding CB1 receptors and genes encoding main degrading enzyme FAAH responsible for pathology in motivation and cognition were identified.

Key words:
endocannabinoids, endocannabinoid system, reward system, addiction, eating disorders.


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