AB0 Blood Groups and Factor V Leiden

Overview

Background.
Jick and his co-workers published in 1969 an observation showing the prevalence of blood group0 being lower in people with thrombosis than in the healthy population. During the next years this finding was severaltimes confirmed. The aim of our work was to answer the question on the distribution of blood groups in individualswith thrombophilia compared to the control group and whether the non-0 blood group increases the thrombosis riskin factor V Leiden carriers. We were also interested in mean values of the ProC Global test in different blood groups.Methods and Results. Factor V Leiden, prothrombin mutation 20210A and ProC Global were examined inindividuals with thrombophilia. The blood group distribution was compared in thrombophilia and control groups.The distribution was statistically different (p=0.000). The mean value of ProC Global in the non-0 carriers was lowerthan in persons with blood group 0.Conclusion. There is a 1.76 times higher thrombosis risk (1/0.5697 = 1.76) in factor V Leiden carriers with bloodgroup non-0 compared to blood group 0. The ProC Global mean values differ in patients with blood group 0 and innon-0 persons.

Key words:
AB0/H blood groups, thrombosis, factor V Leiden, ProC Global.