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proLékaře.cz / Journals / Internal Medicine / 2019 - 1

Diagnostic pitfalls of celiac disease

Czech version

Authors: Iva Hoffmanová 1;  Daniel Sánchez 2;  Helena Tlaskalová Hogenová 2
Authors‘ workplace: II. interní klinika 3. LF UK a FN Královské Vinohrady, Praha 1;  Laboratoř buněčné a molekulární imunologie Mikrobiologického ústavu AV ČR, v. v. i., Praha 2
Published in: Vnitř Lék 2019; 65(1): 24-29
Category:

Overview

Celiac disease is a very common autoimmune disorder caused by the ingestion of dietary gluten products in genetically susceptible persons. Its global prevalence is estimated around 1 %. However, the most cases are not diagnosed. Clinical presentation is widely variable with the involvement of various human systems. Besides a clinical picture (that is often non characteristic), the diagnosis is based on positivity of serological testing (tissue transglutaminase autoantibodies) and histological evaluation of small intestinal mucosa. The article presents a rational diagnostic approach to celiac disease.

Key words:

celiac disease – Marsh classification – tissue transglutaminase autoantibodies – villous atrophy

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