ScreenPro FH – projekt v oblasti screeningu zaměřený na familiární hypercholesterolemii ve střední, jižní a východní Evropě: základní epidemiologie
Authors:
Richard Češka 1; Tomáš Freiberger 2,3; Andrey V. Susekov 4; György Paragh 5; Željko Reiner 6; Lale Tokgözoğlu 7; Katarína Rašlová 8; Maciej Banach 9; Branislav Vohnout 8,11; Andrzej Rynkiewicz 12; Assen Goudev 13; Gheorghe-Andrei Dan 14; Dan Gaiţă 15; Belma Pojskić 16; Ivan Pećin 6; Meral Kayıkçıoğlu 17; Olena Mitchenko 18; Marat V. Ezhov 19; Gustavs Latkovskis 20; Žaneta Petrulionienė 21; Zlatko Fras 22; Nebojsa Tasić 23; Erkin M. Mirrakhimov 24; Tolkun Murataliev 24; Alexander B. Shek 25; Vladimír Tuka 1; Alexandros D. Tselepis 26; Elie M. Moubarak 27; Khalid Al Rasadi 28
Authors‘ workplace:
Paul Stradins Clinical University Hospital, Riga, Latvia
; Third Department of Medicine – Department of Endocrinology and Metabolism of the First Faculty of Medicine, Charles Universit and General University Hospital, Prague, Czech Republic
1; Molecular Genetics Lab, Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic
2; Faculty of Medicine, Masaryk University, Brno, Czech Republic
3; Department of clinical Pharmacology and therapeutics, Academy for Postgraduate Education, Ministry of Health, Russian Federation
4; Institute of Internal Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary
5; Department of Internal Medicine, Division of Metabolic Diseases, School of Medicine University of Zagreb, University Hospital Center Zagreb, Zagreb, Croatia
6; Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey
7; Coordination Center for Familial Hyperlipidemias, Slovak Medical University, Bratislava, Slovakia
8; Department of Hypertension, Medical University of Lodz, Lodz, Poland
9; Institute of Nutrition, FOaZOS, Slovak Medical University, Bratislava, Slovakia
11; Department of Cardiology and Cardiosurgery, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland
12; Queen Giovanna University Hospital, Sofia, Bulgaria
13; University of Medicine Carol Davila, Colentina University Hospital, Bucharest, Romania
14; Institute of Cardiovascular Diseases, University of Medicine & Pharmacy Victor Babes, CardioPrevent Foundation Timisoara, Romania
15; Cantonal hospital, Zenica, Bosnia and Herzegovina
16; Cardiology Department, Ege University Medical School, Lipid Clinic, Izmir, Turkey
17; Institute of Cardiology, AMS Ukraine Dyslipidemia Department, Kiev, Ukraine
18; Russian Cardiology Research and Production Center, Moscow, Russian Federation
19; Latvian Institute of Cardiology and Regenerative Medicine, Faculty of Medicine, University of Latvia
20; Centre of Cardiology and Angiology, Vilnius University Hospital Santariskiu Klinikos, of Cardiology and Angiology, Vilnius, Lithuania
21; Division of Internal Medicine, Preventive Cardiology Unit and Medical Faculty, University of Ljubljana, University Medical Centre Ljubljana, Slovenia
22; Cardiovascular research Centre, Cardiovascular Institute “Dedinje”, Belgrade, Serbia
23; National Centre of Cardiology and Therapy named after academician Mirsaid Mirrakhimov, Kyrgyz State Medical Academy naved after I. K. Akhunbaev, Bishkek, Kyrgyzstan
24; Republican Specialized Center of Cardiology, Tashkent, Uzbekistan
25; Department of Chemistry, University of Ioannina, Atherothrombosis Research Centre, Ioannina, Greece
26; LDL apheresis Centre, Dahr El Bachek Government University Hospital – DGUH, Roumieh – Lebanon
27; College of Medicine and Health Science at Sultan Qaboos University, Sultan Qaboos University Hospital, Muscat, Oman
28
Published in:
Vnitř Lék 2017; 63(1): 25-30
Category:
Original Contributions
Overview
Úvod:
I přes velký pokrok v nedávné době je familiární hypercholesterolemie (FH) stále ještě celosvětově podceňované, nedostatečně diagnostikované, a tedy i nedostatečně léčené onemocnění. O přesné prevalenci pacientů postižených familiární hypercholesterolemií v regionu střední, východní a jižní Evropy (CESE) máme jen velmi málo informací. Cílem studie bylo popsat na základě dostupných údajů epidemiologickou situaci v regionu CESE.
Metody:
Všichni vedoucí představitelé projektu ScreenPro FH v jednotlivých oblastech byli požádáni o poskytnutí lokálních údajů, které se týkají (a) expertního odhadu prevalence FH, (b) již fungujících zdravotnických zařízení, (c) použitých diagnostických kritérií, (d) počtu pacientů již zavedených v místní databázi a konečně (e) dostupnosti možností léčby (zejména plazmaferézy).
Výsledky:
Vzhledem k odhadované prevalenci FH přibližně 1 : 500 odhadujeme, že celková populace FH heterozygotů v regionu CESE zahrnuje 588 363 osob. V místních databázích se však zobrazilo pouze 14 108 osob (2,4 %), přičemž míra zobrazení se lišila v rozmezí od 0,1 % až 31,6 %. Pouze 4 země oznámily dostupnost LDL aferézy.
Závěr:
Naše údaje svědčí o velké populaci pacientů postižených heterozygotní formou FH v regionu CESE a zároveň o nízkých podílech jejich zobrazení. V rámci projektu ScreenPro FH jsou však nyní vytvářeny potřebné struktury a můžeme tak doufat v dosažení příznivějších výsledků.
Klíčová slova:
diagnóza – epidemiologie – familiární hypercholesterolemie – screening
Sources
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