Lethal cases of bleeding to the upper gastrointestinal tract
Authors:
Radek Matlach 1; Pavol Makovický 2; Peter Makovický 3
Authors‘ workplace:
Soudní znalec v oboru zdravotnictví, Prosektura Mimoň
1; Katedra biológie Pedagogickej fakulty Univerzity J. Selyeho, Komárno, Slovenská republika
2; Laboratórium veterinárnej histopatológie Komárno, Slovenská republika
3
Published in:
Vnitř Lék 2016; 62(12): 1028-1033
Category:
Case Reports
Overview
We report three lethal cases of bleeding to the upper gastrointestinal tract as immediate cause of death. The first two cases are in connection with homelessness. First is a male who was found dead in a railway station, seated on a bench with dried blood beneath him. The second is a male who was found lifeless in a wooden shelter, where upon the good will of the landowners, he lived. At autopsy, gastroduodenal ulcer disease with a damaged blood vessel at the ulcer base was found in both. The cause of death was stated as hypovolemic shock, arising from loss of blood from bleeding gastroduodenal ulcer disease. The third case shows a man with liver cirrhosis, who was transported to hospital when his health deteriorated, where he died with blood vomiting. The case was closed as hypovolemic shock from loss of blood and was ascribed to haemorrhagic diathesis and chronic liver insufficiency, and excluded haemoptysis as the cause of the bleeding. The paper draws attention to the risk of mortality in patients with gastroduodenal ulcer disease, with irregular food intake, including alcohol abuse. The cases demonstrate the importance of medical care for patients who are prone to gastric ulcers, or to patients who have been diagnosed and/or treated for gastroduodenal ulcer disease, as the severe risk of ulcer bleeding, leading eventually to ulcer perforation. Our case reports may inform ambulance crews responding to at-risk individuals, such as homeless people, to the immediate threat of possible gastroduodenal ulcer disease with ulcer bleeding, or ulcer perforation.
Key words:
bleeding – death – gastric ulcer – gastroduodenal ulcer disease – nutrition – preventive medicine
Sources
1. Charvát D, Šimša J. Perforace gastroduodenálního vředu. Int Med Prax 2004; 6(12): 583–585.
2. Jurgoš Ľ. Racionálna liečba peptického vredu. Metodický list racionálnej farmakoterapie 2004; 8(3): 1–4.
3. Tachecí I, Bureš J. Gastroduodenální vředová choroba u diabetika. Vnitř Lék 2011; 57(4): 347–350.
4. Povýšil C, Šteiner I et al. Speciální patologie. 2. vyd. Galén: Praha 2007: 148–150. ISBN 978–80–7262–494–2.
5. Hyrdel J. Farmakoterapia peptických vredov. Via Pract 2005; 2(6): 321–325.
6. Tesař T, Foltán V, Huorka M. Farmakoekonomika v terapii peptických vredov. Čes Slov Farm 2002; 51(2): 78–83.
7. Iizasa H, Ishihara S, Richardo T et al. Dysbiotic infection in the stomach. World J Gastroenterol 2015; 21(40): 11450–11457. Dostupné z DOI: <http://dx.doi.org/10.3748/wjg.v21.i40.11450>.
8. Fialová P, Vlček J. Úloha antiulcerózních léčiv v léčbě a prevenci gastropatií vyvolaných nesteroidnými antirevmatiky. Vnitř Lék 2004; 50(11): 858–866.
9. Iwamoto J, Saito Y, Honda A et al. Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy. World J Gastroenterol 2013; 19(11): 1673–1682. Dostupné z DOI: <http://dx.doi.org/10.3748/wjg.v19.i11.1673>.
10. Rybár I, Hlísta M, Masaryk P et al. Podiel gastroduodenálních komplikácií vo vzťahu k liečbe nesteroidními antiflogistikami v Slovenskej republike: ročná prospektívna štúdia. Vnitř Lék 2006; 52(7–8): 673–676.
11. Karkkainen JM, Miilunpohja S, Rantanen T et al. Alcohol abuse increases rebleeding risk and mortality in patients with non-variceal upper gastrointestinal bleeding. Dig Dis Sci 2015; 60(12): 3707–3715. Dostupné z DOI: <http://dx.doi.org/10.1007/s10620–015–3806–6>.
12. Milosavljevic T, Kostic-Milosavljevic M, Krstic M et al. Epidemiological trends in stomach-related diseases. Dig Dis 2014; 32(3): 213–216. Dostupné z DOI: <http://dx.doi.org/10.1159/000357852>.
13. Satinský I. Perforovaný peptický vřed – předoperační rizika, pooperační morbidita a mortalita, profylaxe v intenzivní péči a doporučení. Anest Intenziv Med 2012; 23(5): 259–263.
14. Baron JH. Peptic ulcer. Mt Sinai J Med 2000; 67(1): 58–62.
15. Camici M. Death of Napoleon Bonaparte. Minerva Med 2003; 94(3): 191–195.
16. Seifert B. Aktuální pohled praktického lékaře na dyspeptický syndrom. Folia Gastroenterol Hepatol 2007; 5(2): 9–15.
17. Ng CY, Squires TJ, Busuttil A. Acute abdomen as a cause of death in sudden unexpected deaths in the elderly. Scott Med J 2007; 52(1): 20–23.
18. De-Giorgio F, Lodise M, Pascali VL et al. An unusual case showing fatal rupture of a gastric ulcer or gastromalacia? The importance/role of histology for differential diagnosis. J Forensic Sci 2015; 60(1): 240–242. Dostupné z DOI: <http://dx.doi.org/10.1111/1556–4029.12665>.
19. Luthi F, Kaeser P, Hebert D et al. Cardiac perforation of a gastric ulcer: An unusual cause of death after esophagogastric resection for epidermoid carcinoma of the esophagus. Rev Med Suisse 1999; 119(1): 59–62.
20. Kane E, Fried G, McSherry CK. Perforated peptic ulcer in the elderly. J Am Geriatr Soc 1981; 29(5): 224–227.
21. Smatanová M. Problematika náhlých úmrtí a využití nových především molekulárně genetických analýz. Disertační práce. FN Ostrava 2009. Dostupné z WWW: <https://theses.cz/id/32ji01?lang=en>.
22. Belanová V, Gřiva M. Antitrombotická léčba a nevarikózní krvácení do horní části gastrointestinálního traktu. Vnitř Lék 2015; 61(12): 1016–1022.
23. Svoboda P, Ehrmann J, Klvana P et al. Jiný pohled na akutní krvácení do horního trávicího traktu u pacientů s jaterní cirhózou. Vnitř Lék 2010; 56(11): 1116–1121.
24. Marmo R, Del Piano M, Rotondano G et al. Mortality from non-nulcer bleeding is similar to that of ulcer bleeding in high-risk patients with nonvariceal hemorrhage: a prospective database study in Italy. Gastrointest Endosc 2012; 75(2): 263–272. Dostupné z DOI: <http://dx.doi.org/10.1016/j.gie.2011.07.066>.
25. Gonzalez-Gonzalez JA, Garcia-Compean D, Vazquez-Elizondo G et al. Nonvariceal upper gastrointestinal bleeding in patients with liver cirrhosis. Clinical features, outcomes and predictors of in-hospital mortality. A prospective study. Ann Hepatol 2011; 10(3): 287–295.
26. Machytka E, Ehrmann J, Svoboda P et al. Dlouhodobé sledování pacientů s klinickými známkami krvácení do horní části trávícího traktu a negativním endoskopickým nálezem. Vnitř Lék 2007; 53(9): 942–946.
27. Lata J, Kroupa R, Novotný I et al. Akutní krvácení z horní části gastrointestinálního traktu. Vnitř Lék 2009; 55(Supl 1): 29–33.
28. Suzuki H, Hasegawa I, Hoshino N et al. Two forensic autopsy cases of death due to upper gastrointestinal hemorrhage: a comparison of postmortem computed tomography and autopsy findings. Leg Med (Tokyo) 2015; 17(3): 198–200. Dostupné z DOI: <http://dx.doi.org/10.1016/j.legalmed.2014.12.010>.
29. Reicher JJ, Mindelzun R. Case report: benign gastric ulcer erosion leading to a gastropericardial fistula in a patient with no known risk factors. Clin Imaging 2014; 38(4): 547–549. Dostupné z DOI: <http://dx.doi.org/10.1016/j.clinimag.2014.02.005>.
30. Ohsaka T, Sakai Y, Kuroda K et al. A survey of deaths of homeless people in Osaka city. Nihon Koshu Eisei Zasshi 2003; 50(8): 686–689.
31. Rayburn RL, Pals H, Wright JD. Death, drugs, and disaster: mortality among New Orleans homeless. Care Manag J 2012; 13(1): 8–18.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2016 Issue 12
Most read in this issue
- Thrombophilia
- Coffee as hepatoprotective factor
- Oral antidiabetic drugs in treatment of type 1 diabetes mellitus
- Takotsubo cardiomyopathy: incidence, etiology, complications, therapy and prognosis