Association between asymptomatic hyperuricaemia and metabolic syndrome in the adolescents

Czech version

Authors: Ivana Koborová ¹; Radana Gurecká ¹; Anna Hlavatá ²; Katarína Šebeková ¹
Authors‘ workplace: Ústav molekulárnej biomedicíny LF UK Bratislava, Slovenská republika, prednosta doc. MUDr. Ing. RNDr. Peter Celec, PhD., MPH ¹; II. detská klinika LF UK a Nemocnica akad. L. Dérera, FNsP Bratislava, Slovenská republika, prednosta prof. MUDr. László Kovács, DrSc., MPH ²
Published in: Vnitř Lék 2015; 61(1): 42-49
Category: Reviews

Prednesené v skrátenej forme na 7. slovenskej konferencii detskej nefrológie s medzinárodnou účasťou, 5. – 6. júna 2014 v Košiciach, Slovenská republika.

Overview

In humans, uric acid represents a biologically active end-product of purine nucleotides. Several studies in children and adolescents documented an association between hyperuricaemia and the components metabolic syndrome. High intake of fructose-sweetened beverages might increase uricaemia, since fructose is the only saccharide which metabolism results in the formation of uric acid. Current knowledge does not allow distinguishing whether hyperuricaemia is causally related to the components of metabolic syndrome, or rather represents a marker of an enhanced risk, and poor outcome. No guidelines exist whether or not to treat asymptomatic hyperuricaemia in the adolescents. Randomized controlled prospective clinical studies are needed to elucidate whether uric acid-lowering management would beneficially affect the prevalence of metabolic syndrome, and the incidence of cardiovascular disease.

Key words:
adolescents fructose – insulin resistance– metabolic syndrome – obesity – uric acid

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