Oxidative stress in kidney disease patients

Czech version

Authors: J. Vostálová ¹; A. Galandáková ¹; P. Štrebl ²; J. Zadražil ²; M. Kajabová ³; P. Schneiderka ³
Authors‘ workplace: Ústav lékařské chemie a biochemie Lékařské fakulty UP Olomouc, přednostka prof. RNDr. Jitka Ulrichová, CSc. ¹; III. interní nefrologická, revmatologická a endokrinologická klinika Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Vlastimil Ščudla, CSc. ²; Oddělení klinické biochemie a imunogenetiky FN Olomouc, vedoucí oddělení doc. RNDr. Tomáš Adam, Ph. D. ³
Published in: Vnitř Lék 2012; 58(3): 202-207
Category: Reviews

Overview

Patients with chronic kidney disease are exposed to oxidative stress (OS) that contributes to deterioration of health. Decrease in renal excretory capacity contributes to the accumulation of pro-oxidative substances that are detrimental not only to kidney but to the whole organism including the cardiovascular system. Components of antioxidant system play an important role in the elimination of the OS. The monitoring of antioxidant levels and products of oxidative damage in these patients and the correct interpretation of relationship between these markers and the function of kidney and other organs may contribute to the more effective treatment and health improvement of the patients.

Key words:
reactive oxygen and nitrogen species – antioxidants – kidney – dialysis – transplantation – immunosuppressives

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