Hypoglycaemia – a phenomenon over which modern diabetology manages to prevail

Czech version

Authors: Š. Svačina
Authors‘ workplace: III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Published in: Vnitř Lék 2012; 58(10): 751-754
Category: Reviews

Overview

Hypoglycaemia is considered to be the most significant complication when treating diabetes. The most important is its association with cardiovascular risk. Rigorous self-monitoring, lifestyle changes and the use of insulin analogues reduce the risk significantly in type 1 diabetes patients. Combined insulin and incretin therapy appears to be useful. Individualized therapy and incretin treatment in particular represent considerable risk reduction in type 2 diabetes patients. It is crucial to change therapy in a patient who underwent hypoglycaemia. Modern antidiabetic therapy helps to surmount the risk of hypoglacaemia and it is possible at any stage of type 2 diabetes treatment to select therapy with lover risk of hypoglacaemia: incretin therapy is the most suitable following metformin treatment failure, incretin analogues are the most suitable when oral antidiabetic agents fail, and insulin analogues are the most appropriate when insulin therapy is to be initiated.

Key words:
cardiovascular risk – insulin therapy – incretin therapy – oral antidiabetic medication – insulin analogues

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