Analogues of amylin, α-glucosidase inhibitors and the digestive system in homeostasis regulation

Czech version

Authors: J. Rybka
Authors‘ workplace: Diabetologické centrum Interní kliniky IPVZ, Krajská nemocnice T. Bati, a. s., Zlín, přednosta prim. MUDr. Jiří Latta
Published in: Vnitř Lék 2011; 57(4): 381-387
Category: 12th national Symposium diabetes, "Diabetes and Gastroenterology", Hradec Kralove, 4 to 5 June 2010

Overview

The digestive tract plays an important role in glucose homeostasis. The important fact is that cells of the digestive tract are also the place of production of numerous regulatory peptides. Their use in the treatment of diabetes has been subject to study for many years. The paper examines the synthetic analogue of the human hormone amylin, the secretion of which coincides with the secretion of insulin. The synthetic analogue pramlintide is used in treatment of DM1Tas well as DM2T. Likewise, a group of intestinal α-glukosidase inhibitors – acarbose in this country – was introduced into clinical practice some years ago. Both drugs share their glucose-lowering effects, but first of all they influence postprandial hyperglycemia like other antidiabetic agents of this large group affecting PPG such as incretin mimetics, DPP-4, etc. Both pramlintide and acarbose have find their specific in the treatment of postprandial blood glucose.

Key words:
amylin analogues – pramlintide – α-glucosidase inhibitors – acarbose – miglitol

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