Probiotics in acute pancreatitis – a randomised, placebo- controlled, double‑blind study
Authors:
J. Lata 1; J. Juránková 2; O. Stibůrek 1; V. Příbramská 1; M. Šenkyřík 1; T. Vaňásek 1
Authors‘ workplace:
Interní hepatogastroenterologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MU Dr. Jan Lata, CSc., 2Oddělení klinické mikrobiologie FN Brno, pracoviště Bohunice, přednostka prim. MU Dr. Alena Ševčíková
1
Published in:
Vnitř Lék 2010; 56(2): 111-114
Category:
Original Contributions
Overview
Introduction:
Infections accompanying pancreatitis, particularly pancreatic necroses, represent a serious complication associated with worsening of the disease prognosis. The aim of our study was to explore whether this complication could be prevented by administering a probiotic.
Methods:
The probiotic was administered to 7 patients and placebo to 15. The study was discontinued early following the release of the Propatria study results.
Results:
There was no death in our patient sample and there was no difference between the two groups in microbial colonisation or the length of hospitalization. However, a reduction in endotoxin levels on day 7 and 10 of the hospitalization was observed in the probiotic‑treated group.
Conclusion:
Based on the current knowledge, administration of probiotics in this indication is contraindicated. Nonetheless, reduction in endotoxin levels suggests a positive effect of probiotics on bacterial translocation, the importance of which should be evaluated in the future.
Key words:
acute pancreatitis – probiotics – endotoxin – bacterial translocation
Sources
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
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