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Probio­tics in acute pancreatitis –  a randomised, placebo- controlled, double‑blind study


Authors: J. Lata 1;  J. Juránková 2;  O. Stibůrek 1;  V. Příbramská 1;  M. Šenkyřík 1;  T. Vaňásek 1
Authors‘ workplace: Interní hepatogastroenterologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MU Dr. Jan Lata, CSc., 2Oddělení klinické mikrobio­logie FN Brno, pracoviště Bohunice, přednostka prim. MU Dr. Alena Ševčíková 1
Published in: Vnitř Lék 2010; 56(2): 111-114
Category: Original Contributions

Overview

Introduction:
Infections accompanying pancreatitis, particularly pancreatic necroses, represent a serious complication associated with worsening of the disease prognosis. The aim of our study was to explore whether this complication could be prevented by administering a probio­tic.

Methods:
The probio­tic was administered to 7 patients and placebo to 15. The study was discontinued early following the release of the Propatria study results.

Results:
There was no death in our patient sample and there was no difference between the two groups in microbial colonisation or the length of hospitalization. However, a reduction in endotoxin levels on day 7 and 10 of the hospitalization was observed in the probio­tic‑treated group.

Conclusion:
Based on the current knowledge, administration of probio­tics in this indication is contraindicated. Nonetheless, reduction in endotoxin levels suggests a positive effect of probio­tics on bacterial translocation, the importance of which should be evaluated in the future.

Key words:
acute pancreatitis –  probio­tics –  endotoxin –  bacterial translocation


Sources

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Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

Issue 2

2010 Issue 2

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