Factors related to NT-proBNP values in haemodynamically stable patients with normal systolic function of the left ventricle

Czech version

Authors: M. Vytiska ¹; P. Kala ¹; I. Klabenešová ²; O. Boček ¹; P. Jeřábek ¹; P. Neugebauer ¹; M. Poloczek ¹; J. Pařenica ¹; O. Ludka ¹; J. Špinar ¹
Authors‘ workplace: Interní kardiologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Špinar, CSc., FESC ¹; Oddělení klinické biochemie a hematologie FN Brno, pracoviště Bohunice, přednosta doc. MUDr. Milan Dastych, CSc., MBA ²
Published in: Vnitř Lék 2008; 54(2): 150-155
Category: Original Contributions

Overview

Introduction:
Increased values of natriuretic peptides are considered prognostically significant in normal population with respect to mortality and the incidence of cardiovascular events, regardless of the left ventricular function. The objective of the study is to point out the factors related to NT-proBNP values in patients without the heart failure syndrome and with normal left ventricular systolic function.

Methods:
The group consisted of 290 elective patients aged between 50 and 82, with the mean age of 62 years, of whom 47 % were women. The enrolled patients were heamodynamically stable, without a history of MI, with a normal left ventricular systolic function and with the serum creatinine level < 150 μmol/l. On the same day, the following procedures were performed: left heart catheterisation, NT-proBNP sampling and echocardiographic examination. Diabetes mellitus, hypertension, coronary heart disease, body mass index, age, sex, left ventricular end-diastolic pressure and aortic pulse pressure were chosen as factors with possible impact on the level of NT-proBNP. We used echo parametres to assess the size of the left ventricle, the left ventricular mass index and the presence of left ventricular diastolic function.

Results:
The median of NT-proBNP was 110 pg/ml (min. 11; max. 1,943 pg/ml), and higher values were recorded for116 (i.e. 40 %) of the total number of patients. Based on the above-referred factors, a significant relation was demonstrated between NT-proBNP and age (p < 0.01), sex (p < .01), BMI (p = 0.03), left ventricular size (p = 0.02), left ventricular mass index (p = 0.01), and aortic pulse pressure (p < 0.01).

Conclusion:
The study has shown that the level of NT-proBNP in patients does not solely depend on the haemodynamic status and left ventricular function, but is related to many other risk factors of cardiovascular mortality and morbidity.

Key words:
NT-proBNP and age – sex – pulse pressure – left ventricle

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