Type 1A diabetes mellitus and autoimmunity

Czech version

Authors: D. Vrlíková; M. Mokáň
Authors‘ workplace: I. interná klinika Jesseniovej lekárskej fakulty UK a Martinskej FN, Martin, Slovenská republika, prednosta prof. MUDr. Marián Mokáň, DrSc.
Published in: Vnitř Lék 2005; 51(11): 1297-1302
Category: Review

Overview

Type 1A diabetes mellitus presents the most frequent part of type 1 DM. This disease is caused by an autoimmune destruction of pancreatic β-cells. Genetic, autoimmune and environmental factors are responsible for the development of type 1 diabetes. The most important genes that determinate te development of the disease are genes of Major Histocompatibility Complex (MHC). There is evidence that viral infection acts as a triggering event of autoimmune reaction. The immune response to a microbial determinant would cross-react with host tissues and results in an activation and proliferation of T-lymphocytes that cause destruction of pancreatic β-cells.

Key words:
type 1A diabetes mellitus - HLA-alels - T-lymphocytes - pancreatic β-cells

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