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Complicated course of IBD in pregnancy


Authors: V. Štěpánek 1;  Z. Šerclová 2;  M. Kasalický 3;  M. Bortlík- 4 6
Authors‘ workplace: Gastroenterologické oddělení, Nemocnice České Budějovice, a. s. 1;  Klinické a výzkumné centrum pro střevní záněty, Klinické centrum ISCARE a. s. a 1. LF UK v Praze 2;  Chirurgická klinika 2. LF UK a ÚVN Praha 3;  Interní klinika 1. LF UK a ÚVN Praha 4;  Farmakologický ústav 1. LF UK, Praha 5;  ZSF JČU v Českých Budějovicích, ZSF JČU, České Budějovice 6
Published in: Gastroent Hepatol 2023; 77(1): 30-33
Category:
doi: https://doi.org/10.48095/ccgh202330

Overview

We present a case report of a young female patient with complicated course of inflammatory bowel disease with severe luminal, as well as perianal symptoms. The patient was initially dia­gnosed with ulcerative colitis and underwent proctocolectomy with ileopouch-anal anastomosis. One year after oostomy closure she got pregnant and, at the same time, she developed perianal abscess and fistula. The dia­gnosis was thus changed to Crohn’s disease. During pregnancy, she underwent repeated perianal fistula drainages, surgical revision of ileus and treatment with ustekinumab was started. The patient delivered a healthy boy in November 2022 at 38th gestational week.

Keywords:

ustekinumab – Crohn’s disease – pregnancy – perianal Crohn’s disease


Sources

1. Mitrova K, Pipek B, Bortlik M et al. Safety of Ustekinumab and Vedolizumab During Pregnancy-Pregnancy, Neonatal, and Infant Outcome: A Prospective Multicentre Study. J Crohns Colitis 2022; 16 (12): 1808–1815. doi: 10.1093/ecco-jcc/jjac086.

2. Chaparro M, Kunovský L, Aguas M et al. Surgery due to Inflammatory Bowel Disease During Pregnancy: Mothers and Offspring Outcomes From an ECCO Confer Multicentre Case Series [Scar Study]. J Crohns Colitis 2022; 16 (9): 1428–1435. doi: 10.1093/ecco-jcc/jjac 050.

3. Wetwittayakhlang P, Gonczi L, Lakatos L et al. Long-term Colectomy rates of Ulcerative Colitis over 40-year of Different Therapeutic eras – Results from Western Hungarian Population-based Inception Cohort between 1977–2020. J Crohns Colitis 2022; jjac188. doi: 10.1093/ecco-jcc/jjac188.

4. Atia O, Orlanski-Meyer E, Lujan R et al. Colectomy Rates did not Decrease in Paediatric- and Adult-Onset Ulcerative Colitis During the Biologics Era: A Nationwide Study From the epi-IIRN. J Crohns Colitis 2022; 16 (5): 796–803. doi: 10.1093/ecco-jcc/jjab210.

5. Jarchin L, Spencer EA, Khaitov S et al. De Novo Crohn’s Disease of the Pouch in Children Undergoing Ileal Pouch-Anal Anastomosis for Ulcerative Colitis. J Pediatr Gastroenterol Nutr 2019; 69 (4): 455–460. doi: 10.1097/ MPG.0000000000002406.

6. Zaghiyan K, Kamiński JP, Barmparas G et al. De novo Crohn‘s Disease after Ileal Pouch-Anal Anastomosis for Ulcerative Colitis and Inflammatory Bowel Disease Unclassified: Long-Term Follow-Up of a Prospective Inflammatory Bowel Disease Registry. Am Surg 2016; 82 (10): 977–981.

7. van der Woude CJ, Ardizzone S, Bengtson MB et al. The Second European Evidenced-Based Consensus on Reproduction and Pregnancy in Inflammatory Bowel Disease. J Crohns Colitis 2015; 9 (2): 107–124. doi: 10.1093/ecco-jcc/jju 006.

Labels
Paediatric gastroenterology Gastroenterology and hepatology Surgery

Article was published in

Gastroenterology and Hepatology

Issue 1

2023 Issue 1

Most read in this issue
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