Autoimmune hepatitis after vaccination against COVID-19

Czech version

Authors: V. Pítová ¹; J. Šperl ¹; P. Taimr ¹; O. Fabián ^2,3; T. Miřejovský ²; L. Janoušek ⁴; J. Chlupáč ^4,5; J. Špičák ¹; S. Fraňková ¹
Authors‘ workplace: Klinika hepatogastroenterologie IKEM, Praha ¹; Pracoviště klinické a transplantační patologie IKEM, Praha ²; Ústav patologie a molekulární medicíny 3. LF UK a FTN, Praha ³; Klinika transplantační chirurgie IKEM, Praha ⁴; Ústav anatomie 2. LF UK, Praha ⁵
Published in: Gastroent Hepatol 2023; 77(1): 52-56
Category: Hepatology: case report
doi: https://doi.org/10.48095/ccgh202352

Overview

In this case report, we present a 61-year-old patient admitted to the hospital because of tiredness and jaundice less than three weeks after vaccination against SARS-CoV-2 with the first dose of the Comirnaty vaccine (Pfizer/BioNTech). Based on the patient’s medical history, laboratory data, imaging methods and liver biopsy, we diagnosed autoimmune hepatitis. The patient developed acute liver failure, and his liver function did not improve after corticosteroid administration. Therefore, the patient was enrolled in the waiting list and underwent a successful orthotopic liver transplantation.

Keywords:

vaccination – liver failure – COVID-19 – autoimmune hepatitis

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