Position of vedolizumab in the current treatment of Crohn’s disease

Czech version

Authors: Drastich P.
Authors‘ workplace: Klinika hepatogastroenterologie, Transplantcentrum, IKEM, Praha
Published in: Gastroent Hepatol 2020; 74(2): 148-153
Category:
doi: https://doi.org/10.14735/amgh2020148

Overview

Vedolizumab (VDZ) is a gut-selective anti-integrin monoclonal antibody indicated for the treatment of patients with moderate and severe Crohn’s disease, who have failed conventional or anti-tumour necrosis factor α therapies. The main objectives in Crohn’s disease are to avoid disease complications and preserve the patient’s quality of life. Clinical trials and real-life data have shown that VDZ is effective and safe for the treatment of Crohn’s disease patients. The objective of this article is to present new data and answer practical questions regarding the role of VDZ in the therapy of Crohn’s disease.

Keywords:

vedolizumab – Crohn’s disease – anti-integrin therapy

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