Does proton pump inhibitors treatment affect the risk of gastrointestinal bleeding in patients on novel antithrombotic therapy?

Czech version

Authors: Škorňová I. ¹; Bolek T. ²; Samoš M. ²; Marko J. ¹; Vádelová Ľ. ²; Žolková J. ²; Lányiová Boleková M. ³; Staško J. ¹; Mokáň M. ²
Authors‘ workplace: Národné centrum hemostázy a trombózy, Klinika hematológie a transfuziológie JLF UK a UN Martin ¹; I. Interná klinika JLF UK a UN Martin ²; Radiologická klinika JLF UK a UN Martin ³
Published in: Gastroent Hepatol 2019; 73(4): 319-325
Category: Clinical and Experimental Gastroenterology: Review Article

Overview

Oral antithrombotic therapy significantly increases the risk of gastrointestinal bleeding in patients with acute coronary syndromes or atrial fibrillation. Administration of proton pump inhibitors together with antiplatelet and anticoagulant agents may reduce the risk of gastrointestinal bleeding. Several relatively novel antithrombotic agents have been introduced for patients with acute coronary syndromes (clopidogrel, prasugrel, and ticagrelor) or atrial fibrillation requiring long-term anticoagulation therapy (dabigatran, rivaroxaban, apixaban, and edoxaban). These agents might inhibit platelets or coagulation more than older agents; therefore, the need for gastroprotection might be even greater when these new agents are used for long-term antithrombotic therapy. Consequently, these agents are frequently administered together. This review article summarizes recently reported data about the impact of proton pump inhibitors on the risk of novel antithrombotic therapy-associated bleeding.

Submitted: 26. 6. 2019

Accepted: 13. 8. 2019

Conflict of Interest: The authors declare that the article/ manuscript complies with ethical standards, patient anonymity has been respected, and they state that they have no financial, advisory or other com mercial interests in relation to the subject matter.

Publication Ethics: This article/ manuscript has not been published or is currently be ing submitted for another review.

The authors agree to publish their name and e-mail in the published article/ manuscript.

Dedication: The article/ manuscript was supported by grant APVV no. 16-0020.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Keywords:

gastrointestinal bleeding – proton pump inhibitors – novel oral anticoagulants – ADP receptor blocker therapy

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