Proton pump inhibitors in the light of clinical studies and the safety profile of long-term use

Czech version

Authors: Martin Ďuriček; Peter Bánovčin; R. Hyrdel
Authors‘ workplace: Interná klinika – gastroenterologická JLF UK a UNM
Published in: Gastroent Hepatol 2018; 72(5): 432-440
Category: Clinical and Experimental Gastroenterology: Review Article
doi: https://doi.org/10.14735/amgh2018432

Overview

Proton pump inhibitors are currently one of the most frequently used medicinal drugs. However, although they were initially used primarily for the treatment of gastroesophageal reflux disease and peptic ulcer disease, their indications have considerably widened recently. With the rising prescription rate, the potential adverse effects of long-term treatment with these drugs, described in a growing number of recent reports, is contributing to the increasing concern doctors have about prescribing these drugs and to patient anxiety related to their use, despite clear-cut and correct indications. In this article, we describe the most common undesirable effects of long-term treatment with proton pump inhibitors. The individual effects are supplemented with potential pathophysiological base of origin and quotation of principal studies and interpretations of their results. In the context of recent studies, we conclude that these drugs are safe and when indications for their use are clear, their benefits exceed their possible risks.

Key words:

proton pump inhibitors – safety – risks – adverse effects

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

Submitted: 6. 5. 2018

Accepted: 7. 9. 2018

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