Gliflozins and heart: Analyses of EMPRISE study

Czech version

Authors: Marián Mokáň; Peter Galajda
Authors‘ workplace: I. Interná klinika JLF UK a UN Martin
Published in: Forum Diab 2020; 9(2): 115-119
Category:

Overview

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, gliflozins are a new class of diabetic medications indicated for the treatment of type 2 diabetes mellitus. Apart from glycemic control and low risk of hypoglycemia, gliflozins have been shown to provide significant cardiovascular benefit in patients with type 2 diabetes mellitus. They significantly reduce risk of heart failure, as it was shown in studies EMPAREG-OTCOME with empagliflozin, CANVAS with canagliflozin and DECLARE-TIMI-58 with dapagliflozin in subgroup of patients with high cardiovascular risk. Benefit of empagliflozin in reduced hospitalization for heart failure compared to gliptins, as well as agonists of glucagon like peptide-1, was confirmed also in real word evidence study EMPRISE. There was profit also for patients without cardiovascular disease or heart failure. Study EMPRISE from real world evidence confirmed results from study EMPAREG-OUTCOME, where empagliflozin treatment was associated with reduction of primary cardiovascular composite about 14 %, cardiovascular death about 38 %, total mortality about 32 % and heart failure about 35 %.

Keywords:

type 2 diabetes mellitus – cardiovascular benefit – heart failure – gliflozins – sodium-glucose co-transporter 2 (SGLT2) inhibitors

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