Gliflozins and kidney: Analyses of CREDENCE study

Czech version

Authors: Marián Mokáň; Peter Galajda
Authors‘ workplace: I. Interná klinika JLF UK a UN Martin
Published in: Forum Diab 2020; 9(2): 121-124
Category:

Overview

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, gliflozins are a new possibility of prevention of diabetic kidney disease (nephropathy) in patients with type 2 diabetes mellitus. Apart from glycemic control and low risk of hypoglycemia, gliflozins have been shown to provide significant cardiovascular and nephroprotective benefit. CVOT studies also confirmed the reduction of secondary renal composite by 44 % during the treatment by empagliflozin (study EMPA-REG OUTCOME), by 40 % in canagliflozin treatment (study CANVAS) and by 24 % in the case of dapagliflozin (study DECLARE TIMI-58). New study CREDENCE in diabetic patients with stage 2–3b of chronic kidney disease confirmed nephroprotective effect of canagliflozin in terms of reduction of primary renal composite about 30 %. In patients with diabetic kidney disease treatment with canagliflozin is associated with cardiovascular benefit with reduction of cardiovascular composite about 20 % and hospitalization for heart failure about 39 %. According to new extended SPC canagliflozin is indicated also as addition to standard treatment of patients with diabetic kidney disease in dose 100 mg/day.

Keywords:

gliflozins – diabetic kidney disease – nephroprotective benefit – sodium-glucose co-transporter-2 (SGLT2) inhibitors – study CREDENCE – type 2 diabetes mellitus

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