Mumps – a Reemerging Infection? The Current Incidence of Mumps in the East Bohemian Region in the Czech Republic
Authors:
V. Štěpánová 1; L. Plíšková 2; P. Kosina 3; M. Špliňo 1; M. Főrstl 1; R. Bolehovská 2; J. Dlhý 4; M. Chrzová 5
Authors‘ workplace:
Ústav klinické mikrobiologie
1; Ústav klinické biochemie a diagnostiky
2; Klinika infekčních nemocí Fakultní nemocnice Hradec Králové a Lékařské fakulty UK
v Hradci Králové
3; KHS Královéhradeckého kraje
4; Univerzita Hradec Králové
5
Published in:
Epidemiol. Mikrobiol. Imunol. 55, 2006, č. 4, s. 127-135
Overview
A review of mumps outbreaks among both non-vaccinated and vaccinated children and young adults in the East Bohemian region in 2003–2005 is presented. A significant increase in mumps cases was observed over this period. The clinical diagnosis was confirmed serologically by ELISA detection of IgM antibodies and/or IgG seroconversion and increased levels of IgG antibodies. A reverse transcriptase nested PCR was introduced for direct detection of mumps virus RNA from clinical specimens (nasopharyngeal secretion, saliva, CSF and serum). The isolated RNA will be stored for further analysis and mumps virus genotyping attempts, helpful in tracing the virus circulation in the East Bohemia region. Possible causes of the recent significant increase in mumps cases among the vaccinated population in the Czech Republic are discussed.
Key words:
mumps virus – mumps – serology – PCR – vaccination.
Labels
Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
2006 Issue 4
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