Clinical data on the use of insulin glargine 300 U/ml in adult and paediatric populations with type 1 diabetes and their meta-analysis

Czech version

Authors: Peter Novodvorský ^1,2
Authors‘ workplace: metabolické centrum s. r. o., Trenčín ¹; Department of Oncology & Metabolism, Medical School, University of Sheffield, United Kingdom ²
Published in: Diab Obez 2020; 20(40): 78-83
Category: Reviews

Overview

People with type 1 diabetes (T1D) are dependent on regular application of insulin from the time of the diagnosis and for the rest of their lives. Good metabolic compensation reduces the risk of long-term diabetic complications. These efforts are hampered, however, by the proportionally increased risk of hypoglycaemia and severe hypoglycaemia. The right choice of insulin preparation, timing and the mode of its application are therefore key factors in the management of this condition. In this work the author presents clinical trials examining the use of second-generation basal insulin analog glargine 300 U/ml in adult and pediatric populations of people with T1D and their meta-analysis. These data confirm efficacy and safety of glargine 300 U/ml in this population with a concomitant decreased risk of severe hypoglycaemia, in particular in the titration period (compared with insulin glargine 100 U/ml).

Keywords:

basal insulin – glargine 300 U/ml – glargine 100 U/ml – hypoglycaemia – insulin degludec – nocturnal hypoglycaemia – type 1 diabetes (T1D)

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