Lymph node metastasis of Merkel cell carcinoma without known cutaneous primary - case report
Authors:
Arpád Szabó 1; Igor Richter 2,7; Dana Frydrychová 3; Martina Saláková 4,5; Tomáš Jirásek 1,6
Authors‘ workplace:
Ústav patologie 3. LF UK a Fakultní nemocnice Královské Vinohrady, Praha
1; Komplexní onkologické centrum, Krajská nemocnice Liberec, a. s.
2; Kožní oddělení, Krajská nemocnice Liberec, a. s.
3; Národní referenční laboratoř pro papilomaviry a polyomaviry, Ústav hematologie a krevní transfuze, Praha.
4; Katedra genetiky a mikrobiologie, Přírodovědecká fakulta, Univerzita Karlova, Praha
5; Oddělení patologie, Krajská nemocnice Liberec, a. s.
6; Onkologická klinika 1. LF UK a Thomayerovy nemocnice, Praha
7
Published in:
Čes.-slov. Patol., 53, 2017, No. 3, p. 135-138
Category:
Original Article
Overview
Merkel cell carcinoma is a rare cutaneous tumor with an aggressive clinical course. In most cases it is associated with Merkel cell polyomavirus infection. Exceptionally, the tumor can present as a lymph node metastasis without a discernible cutaneous primary.
In this report we present the case of a 42 year-old man with inguinal lymphadenopathy, histologically consistent with Merkel cell carcinoma. Tumor cells expressed immunohistochemically chromogranin-A, synaptophysin and displayed dot-like positivity for cytokeratin 20. The genome of MCPyV in neoplastic cells was detected using real-time PCR. A cutaneous primary has not been identified neither during the dermatologic examination, nor with PET CT scan.
Keywords:
Merkel cell carcinoma – lymph node metastasis – tumor of unknown primary origin
Sources
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2017 Issue 3
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