Complete Regression of Bone Marrow Fibrosis Following AllogeneicPeripheral Blood Stem Cell Transplantation in a Patient with IdiopathicMyelofibrosis

Czech version

Authors: P. Benešová ¹; K. Dědič ¹; P. Žák ²; J. Voglová ²
Authors‘ workplace: Fingerlandův ústav patologie, Fakultní nemocnice, Hradec Králové 2II. interní klinika – Oddělení klinické hematologie, Fakultní nemocnice, Hradec Králové ¹
Published in: Čes.-slov. Patol., , 2004, No. 4, p. 167-171
Category:

Overview

The authors present a case of a 47-year-old man with idiopathic myelofibrosis. The diagnosis ofmyelofibrosis was made in 1981. Because of progression of the disease and failure of hematopoiesisin 2002, allogeneic peripheral blood stem cell transplantation was performed; the donor was anHLA identical relative. Six months after transplantation, trephin biopsies were made and a completeregression of bone marrow fibrosis was documented. It is the first case of this treatment foridiopathic myelofibrosis in the University Hospital in Hradec Králové.

Key words:
allogeneic transplantation – stem cells – myelofibrosis

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Article was published in

Czecho-Slovak Pathology

2004 Issue 4